Bleys, J., Navas-Acien, Ana, Laclaustra, Martin, Pastor-Barriuso, R., Menke, A., Ordovas, Jose M., Stranges, Saverio and Guallar, Eliseo. (2009) Serum selenium and peripheral arterial disease : results from the National Health and Nutrition Examination Survey, 2003-2004. American Journal of Epidemiology, Vol.169 (No.8). pp. 996-1003. ISSN 0002-9262

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Abstract

The authors conducted a cross-sectional study of the association of serum selenium with the prevalence of peripheral arterial disease among 2,062 US men and women 40 years of age or older participating in the National Health and Nutrition Examination Survey, 2003–2004. Serum selenium was measured by using inductively coupled plasma-dynamic reaction cell-mass spectrometry. Peripheral arterial disease was defined as an ankle-brachial blood pressure index <0.90. The age-, sex-, and race-adjusted prevalence of peripheral arterial disease decreased with increasing serum selenium (P for linear trend = 0.02), but there was an indication of an upturn in risk in the highest quartile of serum selenium. The fully adjusted odds ratios for peripheral arterial disease comparing selenium quartiles 2, 3, and 4 with the lowest quartile were 0.75 (95% confidence interval: 0.37, 1.52), 0.58 (95% confidence interval: 0.28, 1.19), and 0.67 (95% confidence interval: 0.34, 1.31), respectively. In spline regression models, peripheral arterial disease prevalence decreased with increasing serum selenium levels up to 150–160 ng/mL, followed by a gradual increase at higher selenium levels. The association between serum selenium levels and the prevalence of peripheral arterial disease was not statistically significant, although a U-shaped relation was suggested.

Item Type:	Journal Article
Subjects:	R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine
Divisions:	Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Selenium -- Analysis -- United States -- Statistics, Selenium in human nutrition -- Analysis -- United States -- Statistics, Blood lipids, Peripheral vascular diseases, Cardiovascular system -- Diseases, Antioxidants, National Health and Nutrition Examination Survey (U.S.)
Journal or Publication Title:	American Journal of Epidemiology
Publisher:	Oxford University Press
ISSN:	0002-9262
Official Date:	April 2009
Volume:	Vol.169
Number:	No.8
Page Range:	pp. 996-1003
Identification Number:	10.1093/aje/kwn414
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	National Institute of Environmental Health Sciences (NIEHS), American Heart Association (AHA)
Grant number:	1 R01 ES012673 (NIEHS), 0230232N (AHA)
URI:	http://wrap.warwick.ac.uk/id/eprint/37366

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