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Impaired fasting glucose and recurrent cardiovascular disease among survivors of a first acute myocardial infarction : evidence of a sex difference? The Western New York experience
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Donahue, Richard P., Dorn, Joan M., Stranges, Saverio, Swanson, M., Hovey, K. and Trevisan, Maurizio. (2011) Impaired fasting glucose and recurrent cardiovascular disease among survivors of a first acute myocardial infarction : evidence of a sex difference? The Western New York experience. Nutrition, Metabolism and Cardiovascular Diseases, Vol.21 (No.7). pp. 504-511. ISSN 09394753
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Official URL: http://dx.doi.org/10.1016/j.numecd.2009.11.012
Abstract
Background and aims: There is little epidemiological evidence regarding the association of impaired glucose metabolism with recurrent cardiovascular events. We therefore examined potential sex differences in the effect of impaired fasting glucose (IFG) on recurrent cardiovascular disease (CVD) in a community-based study of survivors of a first acute myocardial infarction (MI). Methods and results: This report focuses on 1226 incident MI cases (28.4% women) discharged alive from area hospitals in the Western New York Acute MI Study (1996–2004). Deaths and underlying cause of death were determined via query of the National Death Index (Plus) Retrieval Program with follow-up through December 31, 2004. Outcomes reported included fatal or non-fatal coronary heart disease (CHD) or coronary revascularization surgery and total stroke. Traditional CHD risk factors and other explanatory variables were determined by clinical examination after the first acute event. Impaired fasting glucose was defined as fasting blood glucose between 100 and 125mg/dl. During a mean follow-up of 4.5 years, there were 91 recurrent events (26.1%) in women and 173 recurrent events (19.7%) in men. After multivariable adjustment, the hazard ratios for recurrent cardiovascular events were 1.96 (95% CI: 1.15–3.16) and 2.59 (1.56–4.30) in women with IFG and with diabetes, respectively, compared to normoglycemic women. Among men, neither IFG nor diabetes was independently related to risk of recurrence. Conclusions: In this study, IFG was a strong risk factor for recurrent cardiovascular events only among women. These results suggest that increased cardiovascular risk in MI survivors begins at lower glucose levels in women than men.
| Item Type: | Journal Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) R Medicine > RB Pathology R Medicine > RC Internal medicine |
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School |
| Library of Congress Subject Headings (LCSH): | Glucose -- Physiological effect, Cardiovascular system -- Diseases -- Sex factors, Myocardial infarction -- Research, Sex factors in disease |
| Journal or Publication Title: | Nutrition, Metabolism and Cardiovascular Diseases |
| Publisher: | Elsevier Ltd |
| ISSN: | 09394753 |
| Date: | July 2011 |
| Volume: | Vol.21 |
| Number: | No.7 |
| Page Range: | pp. 504-511 |
| Identification Number: | 10.1016/j.numecd.2009.11.012 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Funder: | National Institute on Alcohol Abuse and Alcoholism (U.S.) (NIAAA), National Institutes of Health (U.S.) (NIH) |
| Grant number: | 2 P50 AA09802-06 (NIAAA), HL 08561 (NIH) |
| URI: | http://wrap.warwick.ac.uk/id/eprint/37379 |
Data sourced from Thomson Reuters' Web of Knowledge
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