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A commentary on the NICE guideline on identification and management of familial hypercholesterolaemia
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Seed, Mary, Humphries, Steve E. and Thorogood, Margaret. (2009) A commentary on the NICE guideline on identification and management of familial hypercholesterolaemia. Primary Care Cardiovascular Journal (PCCJ), Vol.2 (No.3). pp. 141-144. ISSN 1756-5138
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Official URL: http://dx.doi.org/10.3132/pccj.2009.053
Abstract
Background: Familial hypercholesterolaemia (FH) is a genetic disorder with high serum cholesterol levels, early atherosclerosis and a high risk of premature coronary heart disease. It is both under-diagnosed and inadequately treated in some people, although the statin class of drugs is effective in reducing both morbidity and mortality. Recommendations: The basis for a diagnosis of FH is an LDL cholesterol (LDL-C) level of greater than 4.9 mmol/L in an adult or 4.0 mmol/L in a child under 16, combined with either, or both, a family history or clinical signs (xanthomata). Diagnosis can also be made by a genetic test. Because of the high risk of coronary heart disease, adults over 18 years should be treated with a high-potency statin. Patients should be reviewed at least annually, including a review of cardiovascular symptoms or risk factors. Primary care physicians should have a low threshold of suspicion for referral to a specialist in cardiology. Women of childbearing age need particular advice regarding contraception and specialist care in pregnancy. Children should be referred to a specialist centre for treatment.
| Item Type: | Journal Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) R Medicine > RC Internal medicine R Medicine > RJ Pediatrics |
| Divisions: | Faculty of Medicine > Warwick Medical School |
| Library of Congress Subject Headings (LCSH): | Hypercholesteremia -- Diagnosis, Hypercholesteremia -- Treatment, Hyperlipidemia in children, Hypercholesteremia in children, Coronary heart disease |
| Journal or Publication Title: | Primary Care Cardiovascular Journal (PCCJ) |
| ISSN: | 1756-5138 |
| Date: | July 2009 |
| Volume: | Vol.2 |
| Number: | No.3 |
| Page Range: | pp. 141-144 |
| Identification Number: | 10.3132/pccj.2009.053 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| URI: | http://wrap.warwick.ac.uk/id/eprint/37437 |
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