A commentary on the NICE guideline on identification and management of familial hypercholesterolaemia
Seed, Mary, Humphries, Steve E. and Thorogood, Margaret. (2009) A commentary on the NICE guideline on identification and management of familial hypercholesterolaemia. Primary Care Cardiovascular Journal (PCCJ), Vol.2 (No.3). pp. 141-144. ISSN 1756-5138Full text not available from this repository.
Official URL: http://dx.doi.org/10.3132/pccj.2009.053
Background: Familial hypercholesterolaemia (FH) is a genetic disorder with high serum cholesterol levels, early atherosclerosis and a high risk of premature coronary heart disease. It is both under-diagnosed and inadequately treated in some people, although the statin class of drugs is effective in reducing both morbidity and mortality.
Recommendations: The basis for a diagnosis of FH is an LDL cholesterol (LDL-C) level of greater than 4.9 mmol/L in an adult or 4.0 mmol/L in a child under 16, combined with either, or both, a family history or clinical signs (xanthomata). Diagnosis can also be made by a genetic test.
Because of the high risk of coronary heart disease, adults over 18 years should be treated with a high-potency statin. Patients should be reviewed at least annually, including a review of cardiovascular symptoms or risk factors. Primary care physicians should have a low threshold of suspicion for referral to a specialist in cardiology. Women of childbearing age need particular advice regarding contraception and specialist care in pregnancy. Children should be referred to a specialist centre for treatment.
|Item Type:||Journal Article|
|Subjects:||R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
R Medicine > RJ Pediatrics
|Divisions:||Faculty of Medicine > Warwick Medical School|
|Library of Congress Subject Headings (LCSH):||Hypercholesteremia -- Diagnosis, Hypercholesteremia -- Treatment, Hyperlipidemia in children, Hypercholesteremia in children, Coronary heart disease|
|Journal or Publication Title:||Primary Care Cardiovascular Journal (PCCJ)|
|Official Date:||July 2009|
|Page Range:||pp. 141-144|
|Access rights to Published version:||Restricted or Subscription Access|
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