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Advice to use topical or oral ibuprofen for chronic knee pain in older people : randomised controlled trial and patient preference study
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TOIB study team (Including: Underwood, M. (Martin) M.D., Ashby, Deborah, Cross, Pamela, Hennessy, Enid, Letley, Louise, Martin, Jeannett, Mt-Isa, Shahrul, Parsons, Suzanne, Vickers, Madge and Whyte, Ken). (2008) Advice to use topical or oral ibuprofen for chronic knee pain in older people : randomised controlled trial and patient preference study. British Medical Journal, Vol.336 (No.7636). pp. 138-142. ISSN 0959-8146
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Official URL: http://dx.doi.org/10.1136/bmj.39399.656331.25
Abstract
Objective: To determine whether older patients with chronic knee pain should be advised to use topical or oral non-steroidal anti-inflammatory drugs (NSAIDs).
Design: Randomised controlled trial and patient preference study.
Setting: 26 general practices.
Participants: People aged ≥50 with knee pain: 282 in randomised trial and 303 in preference study.
Interventions Advice to use topical or oral ibuprofen.
Primary outcome measures WOMAC (Western Ontario and McMaster Universities) osteoarthritis index, major and minor adverse effects.
Results: Changes in global WOMAC scores at 12 months were equivalent. In the randomised trial the difference (topical minus oral) was two points (95% confidence interval −2 to 6); in the preference study, it was one point (−4 to 6). There were no differences in major adverse effects in the trial or study. The only significant differences in secondary outcomes were in the randomised trial. The oral group had more respiratory adverse effects (17% v 7%,95% confidence interval for difference −17% to −2%), the change in serum creatinine was 3.7 mmol/l less favourable (0.9 µmol/l to 6.5 µmol/l); and more participants changed treatments because of adverse effects (16% v 1%, −16% to −5%). In the topical group more participants had chronic pain grade III or IV at three months, and more participants changed treatment because of ineffectiveness.
Conclusions: Advice to use oral or topical preparations has an equivalent effect on knee pain over one year, and there are more minor side effects with oral NSAIDs. Topical NSAIDs may be a useful alternative to oral NSAIDs.
Trial registration ISRCTN 79353052.
| Item Type: | Journal Article | ||||
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| Subjects: | R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine R Medicine > RM Therapeutics. Pharmacology |
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| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Patient participation, Patient satisfaction, Knee -- Wounds and injuries -- Treatment, Knee -- Diseases -- Treatment, Physician and patient, Nonsteroidal anti-inflammatory agents | ||||
| Journal or Publication Title: | British Medical Journal | ||||
| Publisher: | BMJ Group | ||||
| ISSN: | 0959-8146 | ||||
| Official Date: | January 2008 | ||||
| Dates: |
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| Volume: | Vol.336 | ||||
| Number: | No.7636 | ||||
| Page Range: | pp. 138-142 | ||||
| Identification Number: | 10.1136/bmj.39399.656331.25 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | NHS R & D HTA Programme (Great Britain) (HTA) | ||||
| URI: | http://wrap.warwick.ac.uk/id/eprint/37488 |
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