Hultén, Maj A., Smith, Edward M. and Delhanty, Joy D. A. (2010) Errors in chromosome segregation during oogenesis and early embryogenesis. In: Reproductive Endocrinology and Infertility. Springer: Springer Science and Business Media, pp. 325-342. ISBN 9781441914354

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Abstract

Errors in chromosome segregation occurring during human oogenesis and early embryogenesis are very common. Meiotic chromosome development during oogenesis is subdivided into three distinct phases. The crucial events, including meiotic chromosome pairing and recombination, take place from around 11 weeks until birth. Oogenesis is then arrested until ovulation, when the first meiotic division takes place, with the second meiotic division not completed until after fertilization. It is generally accepted that most aneuploid fetal conditions, such as trisomy 21 Down syndrome, are due to maternal chromosome segregation errors. The underlying reasons are not yet fully understood. It is also clear that superimposed on the maternal meiotic chromosome segregation errors, there are a large number of mitotic errors taking place post-zygotically during the first few cell divisions in the embryo. In this chapter, we summarise current knowledge of errors in chromosome segregation during oogenesis and early embryogenesis, with special reference to the clinical implications for successful assisted reproduction.

Item Type:	Book Item
Subjects:	Q Science > QH Natural history R Medicine > RG Gynecology and obstetrics
Divisions:	Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)
Library of Congress Subject Headings (LCSH):	Oogenesis, Embryology, Human chromosome abnormalities, Meiosis
Publisher:	Springer Science and Business Media
Place of Publication:	Springer
ISBN:	9781441914354
Book Title:	Reproductive Endocrinology and Infertility
Date:	2010
Volume:	Vol.2
Page Range:	pp. 325-342
Identification Number:	10.1007/978-1-4419-1436-1_20
Status:	Peer Reviewed
Access rights to Published version:	Open Access
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URI:	http://wrap.warwick.ac.uk/id/eprint/3796

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