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Errors in chromosome segregation during oogenesis and early embryogenesis

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Hultén, Maj A., Smith, Edward M. and Delhanty, Joy D. A. (2010) Errors in chromosome segregation during oogenesis and early embryogenesis. In: Reproductive Endocrinology and Infertility. Springer: Springer Science and Business Media, pp. 325-342. ISBN 9781441914354

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Official URL: http://dx.doi.org/10.1007/978-1-4419-1436-1_20

Abstract

Errors in chromosome segregation occurring during human oogenesis and early embryogenesis are very common. Meiotic chromosome development during oogenesis is subdivided into three distinct phases. The crucial events, including meiotic chromosome pairing and recombination, take place from around 11 weeks until birth. Oogenesis is then arrested until ovulation, when the first meiotic division takes place, with the second meiotic division not completed until after fertilization. It is generally accepted that most aneuploid fetal conditions, such as trisomy 21 Down syndrome, are due to maternal chromosome segregation errors. The underlying reasons are not yet fully understood. It is also clear that superimposed on the maternal meiotic chromosome segregation errors, there are a large number of mitotic errors taking place post-zygotically during the first few cell divisions in the embryo. In this chapter, we summarise current knowledge of errors in chromosome segregation during oogenesis and early embryogenesis, with special reference to the clinical implications for successful assisted reproduction.

Item Type:

Book Item

Subjects:

Q Science > QH Natural history
R Medicine > RG Gynecology and obstetrics

Divisions:

Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)

Library of Congress Subject Headings (LCSH):

Oogenesis, Embryology, Human chromosome abnormalities, Meiosis

Publisher:

Springer Science and Business Media

Place of Publication:

Springer

ISBN:

9781441914354

Book Title:

Reproductive Endocrinology and Infertility

Official Date:

2010

Dates:

Date	Event
2010	Published

Volume:

Vol.2

Page Range:

pp. 325-342

Identification Number:

10.1007/978-1-4419-1436-1_20

Status:

Peer Reviewed

Access rights to Published version:

Open Access

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