Smith, Stephen M., 1968-, Miller, Karla L., Salimi-Khorshidi, Gholamreza, Webster, Matthew, Beckmann, Christian F., Nichols, Thomas E., Ramsey, Joseph D. and Woolrich, Mark W.. (2010) Network modelling methods for FMRI. NeuroImage, Vol.54 (No.2). pp. 875-891. ISSN 1053-8119

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Abstract

There is great interest in estimating brain “networks” from FMRI data. This is often attempted by identifying a set of functional “nodes” (e.g., spatial ROIs or ICA maps) and then conducting a connectivity analysis between the nodes, based on the FMRI timeseries associated with the nodes. Analysis methods range from very simple measures that consider just two nodes at a time (e.g., correlation between two nodes' timeseries) to sophisticated approaches that consider all nodes simultaneously and estimate one global network model (e.g., Bayes net models). Many different methods are being used in the literature, but almost none has been carefully validated or compared for use on FMRI timeseries data. In this work we generate rich, realistic simulated FMRI data for a wide range of underlying networks, experimental protocols and problematic confounds in the data, in order to compare different connectivity estimation approaches. Our results show that in general correlation-based approaches can be quite successful, methods based on higher-order statistics are less sensitive, and lag-based approaches perform very poorly. More specifically: there are several methods that can give high sensitivity to network connection detection on good quality FMRI data, in particular, partial correlation, regularised inverse covariance estimation and several Bayes net methods; however, accurate estimation of connection directionality is more difficult to achieve, though Patel's τ can be reasonably successful. With respect to the various confounds added to the data, the most striking result was that the use of functionally inaccurate ROIs (when defining the network nodes and extracting their associated timeseries) is extremely damaging to network estimation; hence, results derived from inappropriate ROI definition (such as via structural atlases) should be regarded with great caution.

Item Type:	Journal Article
Subjects:	Q Science > QA Mathematics R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions:	Faculty of Science > Statistics Faculty of Science > WMG (Formerly the Warwick Manufacturing Group)
Library of Congress Subject Headings (LCSH):	Magnetic Resonance Imaging -- methods, Brain -- Magnetic resonance imaging, Brain mapping -- Data processing, Computational neuroscience, Neural networks (Neurobiology) -- Mathematical models
Journal or Publication Title:	NeuroImage
Publisher:	Elsevier
ISSN:	1053-8119
Date:	3 September 2010
Volume:	Vol.54
Number:	No.2
Number of Pages:	17
Page Range:	pp. 875-891
Identification Number:	10.1016/j.neuroimage.2010.08.063
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/38180

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