Albin, R. L., Koeppe, Robert Allen, Wernette, K., Zhuang, W., Nichols, Thomas E., Kilbourn, M. R. and Frey, K. A.. (2009) Striatal [11C]dihydrotetrabenazine and [11C]methylphenidate binding in Tourette syndrome. Neurology, Vol.72 (No.16). pp. 1390-1396. ISSN 0028-3878

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Abstract

Objective: Tourette syndrome (TS) is a common neurodevelopmental disorder marked by tics and behavioral comorbidities. Clinical pharmacology suggests that dopaminergic signaling abnormalities are part of the pathophysiology of TS. Prior molecular imaging studies of nigrostriatal dopaminergic terminal markers report conflicting results. Our goal was to characterize the distribution of nigrostriatal dopaminergic terminals in subjects with TS.

Methods: Thirty-three adult subjects with TS were studied with PET using [11C]dihydrotetrabenazine (DTBZ), a ligand for the type 2 vesicular monoamine transporter, and with [11C] methylphenidate (MP), a ligand for the plasmalemmal dopamine transporter. Subjects were characterized with standard rating instruments for tic severity, obsessive-compulsive behaviors, and attentional deficits.

Results: We found no differences between subjects with TS and control subjects in DTBZ and MP binding in any striatal region. There was no correlation between binding measures and clinical variables. Ventral striatal DTBZ and MP binding distributions in subjects with TS were normal.

Conclusions: We found no evidence of increased striatal dopaminergic innervation in Tourette syndrome (TS). Discrepancy between our present results and those of other studies may be explained by heterogeneity of TS.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry Q Science > QP Physiology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions:	Faculty of Science > Statistics Faculty of Science > WMG (Formerly the Warwick Manufacturing Group)
Library of Congress Subject Headings (LCSH):	Tourette syndrome -- Pathophysiology, Methylphenidate, Ligand binding (Biochemistry)
Journal or Publication Title:	Neurology
Publisher:	Lippincott Williams & Wilkins
ISSN:	0028-3878
Official Date:	21 April 2009
Volume:	Vol.72
Number:	No.16
Number of Pages:	7
Page Range:	pp. 1390-1396
Identification Number:	10.1212/WNL.0b013e3181a187dd
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	VA Merit Review
Grant number:	NS15655, UL1RR024986
URI:	http://wrap.warwick.ac.uk/id/eprint/38211

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