Luo, Wen-Lin and Nichols, Thomas E.. (2003) Diagnosis and exploration of massively univariate neuroimaging models. NeuroImage, Vol. 19 (No. 3). pp. 1014-1032. ISSN 10538119

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Abstract

The goal of this work is to establish the validity of neuroimaging models and inferences through diagnosis and exploratory data analysis. While model diagnosis and exploration are integral parts of any statistical modeling enterprise, these aspects have been mostly neglected in functional neuroimaging. We present methods that make diagnosis and exploration of neuroimaging data feasible. We use three- and one-dimensional summaries that characterize the model fit and the four-dimensional residuals. The statistical tools are diagnostic summary statistics with tractable null distributions and the dynamic graphical tools which allow the exploration of multiple summaries in both spatial and temporal/interscan aspects, with the ability to quickly jump to spatiotemporal detail. We apply our methods to a fMRI data set, demonstrating their ability to localize subtle artifacts and to discover systematic experimental variation not captured by the model.

Item Type:	Journal Article
Subjects:	Q Science > QA Mathematics R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions:	Faculty of Science > Statistics
Library of Congress Subject Headings (LCSH):	Brain -- Imaging -- Mathematical models, Brain -- Imaging -- Statistical methods, Mathematical statistics, Autocorrelation (Statistics)
Journal or Publication Title:	NeuroImage
Publisher:	Elsevier
ISSN:	10538119
Date:	11 June 2003
Volume:	Vol. 19
Number:	No. 3
Page Range:	pp. 1014-1032
Identification Number:	10.1016/S1053-8119(03)00149-6
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/38232

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