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Activation of the medial prefrontal cortex and extended amygdala by individual ratings of emotional arousal : a fMRI study
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Phan, K. Luan, Taylor, Stephan F., Welsh, Robert C., Decker, Laura R., Noll, Douglas C., Nichols, Thomas E., Britton, Jennifer C. and Liberzon, Israel. (2003) Activation of the medial prefrontal cortex and extended amygdala by individual ratings of emotional arousal : a fMRI study. Biological Psychiatry, Vol.53 (No.3). pp. 211-215. ISSN 00063223
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Official URL: http://dx.doi.org/10.1016/S0006-3223(02)01485-3
Abstract
Background:
Significant differences between individual responses to emotional stimuli can be important for the study of emotion. We investigated whether incorporating individual ratings of emotional arousal in the analysis of functional magnetic resonance imaging (fMRI) data improves the detection of activation in the medial prefrontal cortex (MPFC) and sublenticular extended amygdala (SLEA), areas implicated in the processing of emotional salience.
Methods:
Healthy subjects viewed counterbalanced blocks of aversive, nonaversive, and blank images. Outside the scanner, they rated the intensity of emotional arousal (salience) of each presented picture.
Results:
Incorporating the subject’s response to each stimulus by using individualized regressors produced more robust activations within MPFC and SLEA compared with a simple boxcar regressor, identical for all subjects.
Conclusions:
Our findings demonstrate that individual behavioral data are useful in improving detection of activation in block-design functional imaging studies.
| Item Type: | Journal Article |
|---|---|
| Subjects: | B Philosophy. Psychology. Religion > BF Psychology Q Science > QA Mathematics Q Science > QP Physiology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Divisions: | Faculty of Science > Statistics |
| Library of Congress Subject Headings (LCSH): | Magnetic resonance imaging -- Data processing, Prefrontal cortex, Amygdaloid body, Emotions, Block designs |
| Journal or Publication Title: | Biological Psychiatry |
| Publisher: | Elsevier |
| ISSN: | 00063223 |
| Official Date: | 24 January 2003 |
| Volume: | Vol.53 |
| Number: | No.3 |
| Page Range: | pp. 211-215 |
| Identification Number: | 10.1016/S0006-3223(02)01485-3 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| URI: | http://wrap.warwick.ac.uk/id/eprint/38241 |
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