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Genome-wide association study identifies new prostate cancer susceptibility loci
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(2011) Genome-wide association study identifies new prostate cancer susceptibility loci. Human Molecular Genetics, Vol.20 (No.19). pp. 3867-3875. doi:10.1093/hmg/ddr295 ISSN 0964-6906.
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Official URL: http://dx.doi.org/10.1093/hmg/ddr295
Abstract
Prostate cancer (PrCa) is the most common non-skin cancer diagnosed among males in developed countries and the second leading cause of cancer mortality, yet little is known regarding its etiology and factors that influence clinical outcome. Genome-wide association studies (GWAS) of PrCa have identified at least 30 distinct loci associated with small differences in risk. We conducted a GWAS in 2782 advanced PrCa cases (Gleason grade >= 8 or tumor stage C/D) and 4458 controls with 571 243 single nucleotide polymorphisms (SNPs). Based on in silico replication of 4679 SNPs (Stage 1, P < 0.02) in two published GWAS with 7358 PrCa cases and 6732 controls, we identified a new susceptibility locus associated with overall PrCa risk at 2q37.3 (rs2292884, P = 4.3 x 10(-8)). We also confirmed a locus suggested by an earlier GWAS at 12q13 (rs902774, P = 8.6 x 10(-9)). The estimated per-allele odds ratios for these loci (1.14 for rs2292884 and 1.17 for rs902774) did not differ between advanced and non-advanced PrCa (case-only test for heterogeneity P = 0.72 and P = 0.61, respectively). Further studies will be needed to assess whether these or other loci are differentially associated with PrCa subtypes.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > RB Pathology R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Library of Congress Subject Headings (LCSH): | Prostate -- Cancer -- Research, Disease susceptibility -- Genetic aspects, Medical genetics | ||||
Journal or Publication Title: | Human Molecular Genetics | ||||
Publisher: | Oxford University Press | ||||
ISSN: | 0964-6906 | ||||
Official Date: | 2011 | ||||
Dates: |
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Volume: | Vol.20 | ||||
Number: | No.19 | ||||
Page Range: | pp. 3867-3875 | ||||
DOI: | 10.1093/hmg/ddr295 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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