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Common variation at 10p12.31 near MLLT10 influences meningioma risk

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Dobbins, Sara E., Broderick, P. (Peter), Melin, Beatrice, Feychting, Maria, Johansen, Christoffer, Andersson, U. (Ulrika), Brännström, Thomas, Schramm, J. (Johannes), 1946-, Olver, Bianca, Lloyd, Amy et al.
. (2011) Common variation at 10p12.31 near MLLT10 influences meningioma risk. Nature Genetics, Vol.43 (No.9). pp. 825-827. ISSN 1061-4036

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Abstract

To identify susceptibility loci for meningioma, we conducted a genome-wide association study of 859 affected individuals (cases) and 704 controls with validation in two independent sample sets totaling 774 cases and 1,764 controls. We identified a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 x 10(-14)). This finding advances our understanding of the genetic basis of meningioma development.

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Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine
Divisions: Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Meningioma -- Risk factors
Journal or Publication Title: Nature Genetics
Publisher: Nature Publishing Group
ISSN: 1061-4036
Date: September 2011
Volume: Vol.43
Number: No.9
Page Range: pp. 825-827
Identification Number: 10.1038/ng.879
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Cancer Research UK (CRUK), DJ Fielding Medical Research Trust, Great Britain. National Health Service (NHS), European Union (EU), International Union against Cancer (UICC) , Mobile Manufacturers' Forum and Global System for Mobile Communications Association (GSMA), Sweden. Vetenskapsrådet [Research Council] (SRC), Cancer Foundation of Northern Sweden (CFNS), Riksföreningen mot cancer [Swedish Cancer Society], Nordic Cancer Union (NCU), Landsforeningen til kræftens bekæmpelse (Denmark) [Danish Cancer Society], Mobile Telecommunications and Health Research Programme (Great Britain) (MTHR) , Great Britain. Health and Safety Executive (HSE), Great Britain. Dept. of Health (DoE), UK Network Operators' Forum (UKNOF), Emil Aaltonen Foundation (EAF)
Grant number: C1298/A8362 (CRUK), QLK4-CT-1999-01563 (EU)
URI: http://wrap.warwick.ac.uk/id/eprint/38377

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