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Common variation at 10p12.31 near MLLT10 influences meningioma risk

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Dobbins, Sara E., Broderick, P., Melin, Beatrice, Feychting, Maria, Johansen, Christoffer, Andersson, U., Brännström, Thomas, Schramm, J., Olver, Bianca, Lloyd, Amy et al.
(2011) Common variation at 10p12.31 near MLLT10 influences meningioma risk. Nature Genetics, Vol.43 (No.9). pp. 825-827. doi:10.1038/ng.879

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Abstract

To identify susceptibility loci for meningioma, we conducted a genome-wide association study of 859 affected individuals (cases) and 704 controls with validation in two independent sample sets totaling 774 cases and 1,764 controls. We identified a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 x 10(-14)). This finding advances our understanding of the genetic basis of meningioma development.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine
Divisions: Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Meningioma -- Risk factors
Journal or Publication Title: Nature Genetics
Publisher: Nature Publishing Group
ISSN: 1061-4036
Official Date: September 2011
Dates:
DateEvent
September 2011Published
Volume: Vol.43
Number: No.9
Page Range: pp. 825-827
DOI: 10.1038/ng.879
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Cancer Research UK (CRUK), DJ Fielding Medical Research Trust, Great Britain. National Health Service (NHS), European Union (EU), International Union against Cancer (UICC) , Mobile Manufacturers' Forum and Global System for Mobile Communications Association (GSMA), Sweden. Vetenskapsrådet [Research Council] (SRC), Cancer Foundation of Northern Sweden (CFNS), Riksföreningen mot cancer [Swedish Cancer Society], Nordic Cancer Union (NCU), Landsforeningen til kræftens bekæmpelse (Denmark) [Danish Cancer Society], Mobile Telecommunications and Health Research Programme (Great Britain) (MTHR) , Great Britain. Health and Safety Executive (HSE), Great Britain. Dept. of Health (DoE), UK Network Operators' Forum (UKNOF), Emil Aaltonen Foundation (EAF)
Grant number: C1298/A8362 (CRUK), QLK4-CT-1999-01563 (EU)

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