Carter, Cameron S., Mintun, Mark A., Nichols, Thomas E. and Cohen, Jonathan D.. (1997) Anterior cingulate gyrus dysfunction and selective attention deficits in schizophrenia: [15O]H2O PET study during single-trial stroop task performance. The American Journal of Psychiatry, Vol.154 . pp. 1670-1675. ISSN 1535-7228

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Abstract

OBJECTIVE: Attentional deficits are a prominent aspect of cognitive dysfunction in schizophrenia. The anterior cingulate gyrus is proposed to be an important component of frontal attentional control systems. Structural and functional abnormalities have been reported in this region in schizophrenia, but their relationship to attentional deficits is unknown. The authors investigated the function of the anterior cingulate gyrus and the related neural systems that are associated with selective attention in patients with schizophrenia. METHOD: While subjects performed multiple blocks of a single-trial Stroop task, [15O]H2O positron emission tomography scans were obtained. Fourteen patients with schizophrenia were compared with 15 normal subjects matched for age, gender, and parental education. RESULTS: The patients with schizophrenia responded at the same rate but made more errors in color naming during the color-incongruent condition. Consistent with the authors' hypothesis, patients with schizophrenia showed significantly less anterior cingulate gyrus activation while naming the color of color-incongruent stimuli. CONCLUSIONS: Patients with schizophrenia fail to activate the anterior cingulate gyrus during selective attention performance. This finding adds to the understanding of the functional significance of the structural and metabolic abnormalities in schizophrenia that have been previously reported in this region of the brain. (Am J Psychiatry 1997; 154:1670–1675)

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions:	Faculty of Science > Statistics
Library of Congress Subject Headings (LCSH):	Cognition disorders, Schizophrenia, Stroop Color and Word Test, Selectivity (Psychology)
Journal or Publication Title:	The American Journal of Psychiatry
Publisher:	American Psychiatric Publishing, Inc.
ISSN:	1535-7228
Date:	1997
Volume:	Vol.154
Page Range:	pp. 1670-1675
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/38408

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