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Post-ECT increases in MRI regional T2 relaxation times and their relationship to cognitive side effects : a pilot study

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Diehl, David J., Keshavan, Matcheri S., 1953-, Kanal, Emanuel, Nebes, R. D. (Robert D.), Nichols, Thomas E. and Gillen, Joseph S.. (1994) Post-ECT increases in MRI regional T2 relaxation times and their relationship to cognitive side effects : a pilot study. Psychiatry Research, Vol.54 (No.2). pp. 177-184. ISSN 01651781

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Abstract

This pilot study examined the hypothesis that magnetic resonance imaging T2 relaxation times of specific brain regions increase after electroconvulsive therapy (ECT) and that these increases are related to the cognitive side effects of ECT. Six depressed patients undergoing unilateral ECT were studied. The results demonstrate significant post-ECT T2 increases in the right and left thalumus, and suggest a correlation between regional T2 increase and anterograde memory impairment following ECT. These findings are consistent with a post-ECT increase in brain water content (perhaps secondary to a breakdown of the blood-brain barrier) and suggest that this process may be related to the memory impairment following ECT.

Item Type: Journal Article
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Faculty of Science > Statistics
Library of Congress Subject Headings (LCSH): Brain -- Magnetic resonance imaging, Electroconvulsive therapy, Cognition
Journal or Publication Title: Psychiatry Research
Publisher: Elsevier
ISSN: 01651781
Date: 1994
Volume: Vol.54
Number: No.2
Page Range: pp. 177-184
Identification Number: 10.1016/0165-1781(94)90005-1
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
URI: http://wrap.warwick.ac.uk/id/eprint/38422

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