Gayet, Florence, Marty, J. D. (Jean Daniel), Brûlet, Annie and Viguerie, Nancy Lauth-de (2011) Vesicles in ionic liquids. Langmuir, Vol.27 (No.16). pp. 9706-9710. doi:10.1021/la2015989 ISSN 0743-7463.

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Abstract

The formation of vesicles from 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) in several room-temperature ionic liquids, namely, 1-butyl-3-methylimidazolium tetrafluoroborate (BmimBF(4)), 1-butyl-3-methylimidazolium hexafluorophosphate (BmimPF(6)), 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (EmimNTf(2)), and N-benzylpyridinium bis(trifluoromethylsulfonyl)imide (BnPyNTf(2)), as well as in a water/BmimBF(4) mixture, was investigated. In pure ionic liquids, observations by staining transmission electron microscopy demonstrated clearly the formation of spherical structures with diameters of 200-400 nm. The morphological characteristics of these vesicles in ionic liquids, in particular, the membrane thicknesses, were first investigated by small-angle neutron scattering measurements. The mean bilayer thickness was found to be similar to 63 +/- 1 angstrom in a deuterated ionic liquid (BnPyNTf(2)-d). This value was similar to that observed in water. The effect of Its on the modification of the phase physical properties of multilamellar vesicles (MLVs) was then investigated by differential scanning calorimetry. In pure IL as in water, DPPC exhibited an endothermic pretransition followed by the main transition. These transition temperatures and the associated enthalpies in ILs were higher than those in water because of a reduction of the electrostatic repulsion between zwitterionic head groups. To better understand the effect of ionic liquid on the formation of multilamellar vesicles, mixtures of BmimBF(4) and water, which are miscible in all proportions, were analyzed (BmimBF(4)/water ratio from 0% to 100%). SANS and DSC experiments demonstrated that the bilayer structure and stability were strongly modified by the IL content. Moreover, matching SANS experiments showed that BmimBF(4) molecules prefer to be located inside the DPPC membrane rather than in water.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology
Divisions:	Faculty of Science, Engineering and Medicine > Science > Chemistry
Library of Congress Subject Headings (LCSH):	Bilayer lipid membranes, Coated vesicles, Ionic solutions
Journal or Publication Title:	Langmuir
Publisher:	American Chemical Society
ISSN:	0743-7463
Official Date:	August 2011
Dates:	Date Event August 2011 Published
Volume:	Vol.27
Number:	No.16
Page Range:	pp. 9706-9710
DOI:	10.1021/la2015989
Status:	Peer Reviewed
Publication Status:	Published
Funder:	Advantage West Midlands (AWM) , European Regional Development Fund (ERDF)

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