Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells
Ciobanu, Mihai, Huang, Kuo-Ting, Daguer, Jean-Pierre, Barluenga, Sofia, Chaloin, Olivier, Schaeffer, Evelyne, Mueller, Christopher G., Mitchell, Daniel Anthony and Winssinger, Nicolas. (2011) Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells. Chemical Communications, Vol.47 (No.33). pp. 9321-9323. ISSN 1359-7345Full text not available from this repository.
Official URL: http://dx.doi.org/10.1039/c1cc13213j
We report the synthesis of a nucleic acid-encoded carbohydrate library, its combinatorial self-assembly into 37 485 pairs and a screen against DC-SIGN leading to the identification of consensus ligand motifs. A prototypical example from the selected pairs was shown to have enhanced binding. A dendrimer incorporating the selected motifs inhibited gp120's binding to dendritic cells with higher efficiency than mannan.
|Item Type:||Journal Article|
|Subjects:||Q Science > QP Physiology
R Medicine > RM Therapeutics. Pharmacology
|Divisions:||Faculty of Medicine > Warwick Medical School|
|Library of Congress Subject Headings (LCSH):||Oligomers, Drug development, Pharmaceutical chemistry, Oligosaccharides, Peptides, Nucleic acids, DNA-ligand interactions|
|Journal or Publication Title:||Chemical Communications|
|Publisher:||Royal Society of Chemistry|
|Page Range:||pp. 9321-9323|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||European Research Council (ERC), Institut Universitaire de France (IUF)|
|Grant number:||ERC 201749 (ERC)|
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