Ciobanu, Mihai, Huang, Kuo-Ting, Daguer, Jean-Pierre, Barluenga, Sofia, Chaloin, Olivier, Schaeffer, Evelyne, Mueller, Christopher G., Mitchell, Daniel Anthony and Winssinger, Nicolas. (2011) Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells. Chemical Communications, Vol.47 (No.33). pp. 9321-9323. ISSN 1359-7345

Full text not available from this repository.

Abstract

We report the synthesis of a nucleic acid-encoded carbohydrate library, its combinatorial self-assembly into 37 485 pairs and a screen against DC-SIGN leading to the identification of consensus ligand motifs. A prototypical example from the selected pairs was shown to have enhanced binding. A dendrimer incorporating the selected motifs inhibited gp120's binding to dendritic cells with higher efficiency than mannan.

Item Type:	Journal Article
Subjects:	Q Science > QP Physiology R Medicine > RM Therapeutics. Pharmacology
Divisions:	Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Oligomers, Drug development, Pharmaceutical chemistry, Oligosaccharides, Peptides, Nucleic acids, DNA-ligand interactions
Journal or Publication Title:	Chemical Communications
Publisher:	Royal Society of Chemistry
ISSN:	1359-7345
Date:	2011
Volume:	Vol.47
Number:	No.33
Page Range:	pp. 9321-9323
Identification Number:	10.1039/c1cc13213j
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	European Research Council (ERC), Institut Universitaire de France (IUF)
Grant number:	ERC 201749 (ERC)
URI:	http://wrap.warwick.ac.uk/id/eprint/38472

Data sourced from Thomson Reuters' Web of Knowledge

Request changes to a record

Actions (login required)

View Item