Tetrazine-norbornene click reactions to functionalize degradable polymers derived from lactide
Barker, Ian A., Hall, Daniel J., Hansell, Claire F., Du Prez, Filip E., O'Reilly, Rachel K. and Dove, Andrew P.. (2011) Tetrazine-norbornene click reactions to functionalize degradable polymers derived from lactide. Macromolecular Rapid Communications, Vol.32 (No.17). pp. 1362-1366. ISSN 10221336Full text not available from this repository.
Official URL: http://dx.doi.org/10.1002/marc.201100324
Post-polymerization modification of polymers derived from sustainable resources using the click reaction between tetrazines and norbornenes is shown to provide a mild and efficient route for the synthesis of functional degradable polymers. Norbornene chain-end functional poly(lactide) was synthesized using organocatalytic methods and functionalized by the addition of 3,6-di-2-pyridyl-1,2,4,5-tetrazine without degradation of the polymer backbone. The versatility of this reaction was demonstrated by the application of analogues bearing amine and poly(ethylene oxide) groups to realize amine-functional polymers and block copolymers. Poly(spiro[6-methyl-1,4-dioxane-2,5-dione-3,2'-bicyclo[2.2.1]heptene]) was prepared from lactide. The pendant norbornene group on the backbone of the resultant polymer was modified in a similar manner to produce functional degradable polymers and graft co-polymers.
|Item Type:||Journal Article|
|Subjects:||Q Science > QD Chemistry|
|Divisions:||Faculty of Science > Chemistry|
|Library of Congress Subject Headings (LCSH):||Polymers -- Biodegradation, Chemical reactions, Tetrazine|
|Journal or Publication Title:||Macromolecular Rapid Communications|
|Publisher:||Wiley - V C H Verlag GmbH & Co. KGaA|
|Official Date:||1 September 2011|
|Page Range:||pp. 1362-1366|
|Access rights to Published version:||Restricted or Subscription Access|
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