Continuous time dynamic PET imaging using list mode data
Nichols, Thomas E., Qi, Jinyi and Leahy, Richard M. (1999) Continuous time dynamic PET imaging using list mode data. In: IPMI '99 : 16th International Conference on Information Processing in Medical Imaging, Visegrad, Hungary, June 28 - July 2, 1999. Published in: IPMI '99 Proceedings of the 16th International Conference on Information Processing in Medical Imaging pp. 98-111.Full text not available from this repository.
We describe a method for computing a continuous time estimate of dynamic changes in tracer density using list mode PET data. The tracer density in each voxel is modeled as an inhomogeneous Poisson process whose rate function can be represented using a cubic B-spline basis. An estimate of these rate functions is obtained by maximizing the likelihood of the arrival times of each detected photon pair over the control vertices of the spline. By resorting the list mode data into a standard sinogram plus a "timogram" that retains the arrival times of each of the events, we are able to perform efficient computation that exploits the symmetry inherent in the ordered sinogram. The maximum likelihood estimator uses quadratic temporal and spatial smoothness penalties and an additional penalty term to enforce non-negativity. Corrections for scatter and randoms are described and the results of studies using simulated and human data are included.
|Item Type:||Conference Item (Paper)|
|Subjects:||Q Science > QA Mathematics
R Medicine > RC Internal medicine
|Divisions:||Faculty of Science > Statistics|
|Library of Congress Subject Headings (LCSH):||Tomography, Emission -- Mathematical models|
|Journal or Publication Title:||IPMI '99 Proceedings of the 16th International Conference on Information Processing in Medical Imaging|
|Page Range:||pp. 98-111|
|Conference Paper Type:||Paper|
|Title of Event:||IPMI '99 : 16th International Conference on Information Processing in Medical Imaging|
|Type of Event:||Conference|
|Location of Event:||Visegrad, Hungary|
|Date(s) of Event:||June 28 - July 2, 1999|
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