Hayasaka, Satoru and Nichols, Thomas E. (2004) Combining voxel intensity and cluster extent with a permutation test framework. In: 2004 IEEE International Symposium on Biomedical Imaging : From Nano to Macro, Arlington, VA, 15-18 April 2004. Published in: Biomedical Imaging: Nano to Macro, 2004. IEEE International Symposium ISSN 1945-8452. doi:10.1109/ISBI.2004.1398673

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Abstract

Voxel intensity-based tests provide good sensitivity for high intensity signals, whereas cluster extent-based tests are sensitive to spatially extended signals. To benefit from the strength of both, we consider combining intensity and extent information. We generalize previous work by proposing the use of weighted combining functions. Using a combining framework with permutation tests, we consider a variety of ways of combining voxel intensity and cluster extent information without knowing their distribution. Further, we propose meta-combining, a combining function of combining functions, which integrates strengths of multiple combining functions into one single statistic. Using real data, we demonstrate that combined tests can be more sensitive than voxel or cluster size test alone. Though not necessarily sensitive than individual combining functions, the meta-combining function is sensitive to all types of signals, thus can be uses as a single test summarizing all the combining functions.

Item Type:	Conference Item (Paper)
Subjects:	Q Science > QA Mathematics R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions:	Faculty of Science > Statistics
Library of Congress Subject Headings (LCSH):	Brain -- Imaging -- Data processing, Brain -- Imaging -- Statistical methods, Permutations, Cluster analysis -- Simulation methods, Mathematical statistics
Journal or Publication Title:	Biomedical Imaging: Nano to Macro, 2004. IEEE International Symposium
Publisher:	IEEE
Place of Publication:	Washington USA
ISSN:	1945-8452
Official Date:	2004
Dates:	Date Event 2004 Published
DOI:	10.1109/ISBI.2004.1398673
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Version or Related Resource:	Hayasaka, S. and Nichols, T.E. (2004) Combining voxel intensity and cluster extent with permutation test framework. Neuroimage 23(1), pp. 54-63.
Conference Paper Type:	Paper
Title of Event:	2004 IEEE International Symposium on Biomedical Imaging : From Nano to Macro
Type of Event:	Conference
Location of Event:	Arlington, VA
Date(s) of Event:	15-18 April 2004
Related URLs:	Related item in WRAP

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