Reconstructing the history of maize streak virus strain : a dispersal to reveal diversification hot spots and its origin in Southern Africa
. (2011) Reconstructing the history of maize streak virus strain : a dispersal to reveal diversification hot spots and its origin in Southern Africa. Journal of Virology, Vol.85 (No.18). pp. 9623-9636. ISSN 0022-538X Full text not available from this repository.
Official URL: http://dx.doi.org/10.1128/JVI.00640-11
Maize streak virus strain A (MSV-A), the causal agent of maize streak disease, is today one of the most serious biotic threats to African food security. Determining where MSV-A originated and how it spread transcontinentally could yield valuable insights into its historical emergence as a crop pathogen. Similarly, determining where the major extant MSV-A lineages arose could identify geographical hot spots of MSV evolution. Here, we use model-based phylogeographic analyses of 353 fully sequenced MSV-A isolates to reconstruct a plausible history of MSV-A movements over the past 150 years. We show that since the probable emergence of MSV-A in southern Africa around 1863, the virus spread transcontinentally at an average rate of 32.5 km/year (95% highest probability density interval, 15.6 to 51.6 km/year). Using distinctive patterns of nucleotide variation caused by 20 unique intra-MSV-A recombination events, we tentatively classified the MSV-A isolates into 24 easily discernible lineages. Despite many of these lineages displaying distinct geographical distributions, it is apparent that almost all have emerged within the past 4 decades from either southern or east-central Africa. Collectively, our results suggest that regular analysis of MSV-A genomes within these diversification hot spots could be used to monitor the emergence of future MSV-A lineages that could affect maize cultivation in Africa.
|Item Type:||Journal Article|
|Subjects:||Q Science > QR Microbiology > QR355 Virology
S Agriculture > SB Plant culture
|Divisions:||Faculty of Science > Life Sciences (2010- ) > Warwick HRI (2004-2010)|
|Library of Congress Subject Headings (LCSH):||Corn -- Virus diseases, Wheat -- Virus diseases, Corn -- Diseases and pests -- Africa, Mosaic viruses, Gene expression, Phylogeography, Cicadulina|
|Journal or Publication Title:||Journal of Virology|
|Publisher:||American Society for Microbiology|
|Page Range:||pp. 9623-9636|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||National Research Foundation (South Africa) (NRF) , University of Cape Town (UCT), Canon Collins Trust (CCT), Carnegie Corporation of New York , Wellcome Trust (London, England), Fonds voor Wetenschappelijk Onderzoek—Vlaanderen [Research Foundation—Flanders] (FWO), GIS Centre de Recherche et de Veille Sanitaire sur les Maladies Emergentes dans l'Ocean Indien (CRVOI), Réunion. Conseil régional|
|Grant number:||PRAO/AIRD/CRVOI/08/03 (CRVOI)|
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