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Development of a chemotherapy regimen interaction database for the mobile internet : detecting interactions with psychotropics through OncoRx-MI

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Yap, Kevin Yi-Lwern, Chui, Wai Keung and Chan, Alexandre. (2011) Development of a chemotherapy regimen interaction database for the mobile internet : detecting interactions with psychotropics through OncoRx-MI. Informatics for Health and Social Care, Vol.36 (No.3). pp. 132-146. ISSN 1753-8157

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Official URL: http://dx.doi.org/10.3109/17538157.2011.584996

Abstract

Introduction. Cancer patients are at high risk of drug-drug interactions (DDIs). Clinicians need to know the magnitude of DDIs so as to better manage their patients' drug therapies. We have previously created a novel interaction database for oncology prescriptions (OncoRx). In this project, we leverage on 3G networks to further develop this database into an iPhone-specific application for the mobile internet (OncoRx-MI).

Methodology. Data on anticancer drugs (ACDs), chemotherapy regimens (CRegs) and DDIs with psychotropics were compiled from various hardcopy and online resources, and published articles from PubMed, Scopus and Science Direct. The database and iPhone web documents were designed using Adobe Dreamweaver CS4 and associated with a combination of open-source programming scripts.

Results. OncoRx-MI currently detects over 5000 DDIs (69.3% pharmacokinetic, 30.7% pharmacodynamic) between 256 single-agent and combination CRegs with 51 psychotropic drugs. OncoRx-MI fits the iPhone screen configuration, and displays information regarding the regimen, pharmacokinetics of the drugs and detected DDIs in tabular format for improved usability.

Conclusion. OncoRx-MI is the first mobile DDI application of its kind which detects interactions for combination CRegs. Future versions will include DDIs with other drug categories. Usability studies on its impact in clinical practice will also be carried out.

Item Type:

Journal Article

Subjects:

Q Science > QA Mathematics
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RM Therapeutics. Pharmacology

Divisions:

Faculty of Science > WMG (Formerly the Warwick Manufacturing Group)

Library of Congress Subject Headings (LCSH):

iPhone (Smartphone) -- Computer programs, Drug interactions -- Computer programs, Antineoplastic agents -- Computer programs, Chemotherapy -- Computer programs, Psychotropic drugs -- Computer programs

Journal or Publication Title:

Informatics for Health and Social Care

Publisher:

Informa Healthcare

ISSN:

1753-8157

Official Date:

September 2011

Dates:

Date	Event
September 2011	Published

Volume:

Vol.36

Number:

No.3

Number of Pages:

Page Range:

pp. 132-146

Identification Number:

10.3109/17538157.2011.584996

Status:

Peer Reviewed

Publication Status:

Published

Access rights to Published version:

Restricted or Subscription Access

Funder:

National University of Singapore

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