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Novel Corynebacterium diphtheriae in domestic cats

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Hall, Aron J., Cassiday, Pamela K., Bernard, Kathryn A., Bolt, Frances, Steigerwalt, Arnold G., Bixler, Danae, Pawloski, Lucia C., Whitney, Anne M., Iwaki, M., Baldwin, Adam, Dowson, Christopher G., Komiya, Takako, Takahashi, Motohide, Hinrikson, Hans P. and Tondella, Maria L.. (2010) Novel Corynebacterium diphtheriae in domestic cats. Emerging Infectious Diseases , Vol.16 (No.4). ISSN 1080-6059

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Official URL: http://dx.doi.org/10.3201/eid1604.091107

Abstract

Novel nontoxigenic Corynebacterium diphtheriae was isolated from a domestic cat with severe otitis. Contact investigation and carrier study of human and animal contacts yielded 3 additional, identical isolates from cats, although no evidence of zoonotic transmission was identified. Molecular methods distinguished the feline isolates from known C. diphtheriae.

Item Type: Journal Article
Subjects: Q Science > QL Zoology
S Agriculture > SF Animal culture
Divisions: Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)
Library of Congress Subject Headings (LCSH): Corynebacterium diphtheriae, Cats -- Diseases, Otitis in animals, Animals as carriers of disease
Journal or Publication Title: Emerging Infectious Diseases
Publisher: US Department of Health and Human Services
ISSN: 1080-6059
Date: April 2010
Volume: Vol.16
Number: No.4
Identification Number: 10.3201/eid1604.091107
Status: Peer Reviewed
Access rights to Published version: Open Access
Funder: Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Micropathology Ltd., Medical Research Council (Great Britain) (MRC)
References: 1. Vitek CR, Wharton M. Diphtheria toxoid. In: Plotkin SA, Orenstein WA, Offi t PA, editors. Vaccines. 5th ed. Philadelphia: Elsiever; 2008. p. 139–56. 2. Bernard KA, Munro C, Wiebe D, Ongsansoy E. Characteristics of rare or recently described Corynebacterium species recovered from human clinical material in Canada. J Clin Microbiol. 2002;40:4375– 81. DOI: 10.1128/JCM.40.11.4375-4381.2002 3. Funke G, Bernard KA. Coryneform gram-positive rods. In: Murray PR, Baron EJ, Jorgensen JH, Landry ML, Pfaller MA, editors. Manual of clinical microbiology. 9th ed. Washington: ASM Press; 2007. p. 485–514. 4. Clinical Laboratory Standards Institute. M45-A. Methods for antimicrobial dilution and disk susceptibility testing of infrequently isolated or fastidious bacteria. Wayne (PA): The Institute; 2006. 5. Bernard KA, Bellefeuille M, Ewan EP. Cellular fatty acid composition as an adjunct to the identifi cation of asporogenous, aerobic gram-positive rods. J Clin Microbiol. 1991;29:83–9. 6. Engler KH, Glushkevich T, Mazurova IK, George RC, Efstratiou A. A modifi ed Elek test for detection of toxigenic corynebacteria in the diagnostic laboratory. J Clin Microbiol. 1997;35:495–8. 7. Miyamura K, Nishio S, Ito A, Murata R, Kono R. Micro cell culture method for determination of diphtheria toxin and antitoxin titres using VERO cells. I. Studies on factors affecting the toxin and antitoxin titration. J Biol Stand. 1974;2:189–201. DOI: 10.1016/0092- 1157(74)90015-8 8. Schuhegger R, Lindermayer M, Kugler R, Heesemann J, Busch U, Sing A. Detection of toxigenic Corynebacterium diphtheriae and Corynebacterium ulcerans strains by a novel real-time PCR. J Clin Microbiol. 2008;46:2822–3. DOI: 10.1128/JCM.01010-08 9. Mothershed EA, Cassiday PK, Pierson K, Mayer LW, Popovic T. Development of a real-time fl uorescence PCR assay for rapid detection of the diphtheria toxin gene. J Clin Microbiol. 2002;40:4713–9. DOI: 10.1128/JCM.40.12.4713-4719.2002 10. Cassiday PK, Pawloski LC, Tiwari T, Sanden GN, Wilkins PP. Analysis of toxigenic Corynebacterium ulcerans strains revealing potential for false-negative real-time PCR results. J Clin Microbiol. 2008;46:331–3. DOI: 10.1128/JCM.01251-07 11. Weisburg WG, Barns SM, Pelletier DA, Lane DJ. 16S ribosomal DNA amplifi cation for phylogenetic study. J Bacteriol. 1991;173:697–703. 12. Khamis A, Raoult D, La Scola B. rpoB gene sequencing for identifi - cation of Corynebacterium species. J Clin Microbiol. 2004;42:3925– 31. DOI: 10.1128/JCM.42.9.3925-3931.2004 13. Corboz L, Thoma R, Braun U, Zbinden R. Isolation of Corynebacterium diphtheriae subsp. belfanti from a cow with chronic active dermatitis [in German]. Schweiz Arch Tierheilkd. 1996;138:596–9. 14. Henricson B, Segarra M, Garvin J, Burns J, Jenkins S, Kim C, et al. Toxigenic Corynebacterium diphtheriae associated with an equine wound infection. J Vet Diagn Invest. 2000;12:253–7. 15. Bonmarin I, Guiso N, Le Fleche-Mateos A, Patey O, Patrick AD, Levy-Bruhl D. Diphtheria: a zoonotic disease in France? Vaccine. 2009;27:4196–200. DOI: 10.1016/j.vaccine.2009.04.048
URI: http://wrap.warwick.ac.uk/id/eprint/3855

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