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A novel approach to exploring potential interactions among single-nucleotide polymorphisms of inflammation genes in gliomagenesis : an exploratory case-only study
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Amirian, E. Susan, Scheurer, Michael E., Liu, Yanhong, D'Amelio, Anthony M., Houlston, Richard S., Etzel, Carol J., Shete, Sanjay, Swerdlow, Anthony, Schoemaker, Minouk J., McKinney, P. (Patricia), Fleming, S. J., Muir, Kenneth (Kenneth R.), Lophatananon, Artitaya and Bondy, Melissa L.. (2011) A novel approach to exploring potential interactions among single-nucleotide polymorphisms of inflammation genes in gliomagenesis : an exploratory case-only study. Cancer Epidemiology Biomarkers & Prevention, Vol.20 (No.8). pp. 1683-1689. ISSN 1055-9965
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Official URL: http://dx.doi.org/10.1158/1055-9965.EPI-11-0203
Abstract
Background: Despite extensive research on the topic, glioma etiology remains largely unknown. Exploration of potential interactions between single-nucleotide polymorphisms (SNP) of immune genes is a promising new area of glioma research. The case-only study design is a powerful and efficient design for exploring possible multiplicative interactions between factors that are independent of one another. The purpose of our study was to use this exploratory design to identify potential pair wise SNP-SNP interactions from genes involved in several different immune-related pathways for investigation in future studies.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QH Natural history > QH426 Genetics R Medicine > RB Pathology R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| Divisions: | Faculty of Medicine > Warwick Medical School |
| Library of Congress Subject Headings (LCSH): | Gliomas -- Etiology, Chromosome polymorphism, Gliomas -- Risk factors, Gliomas -- Epidemiology, Genetic polymorphisms, Cellular signal transduction |
| Journal or Publication Title: | Cancer Epidemiology Biomarkers & Prevention |
| Publisher: | American Association for Cancer Research |
| ISSN: | 1055-9965 |
| Date: | August 2011 |
| Volume: | Vol.20 |
| Number: | No.8 |
| Page Range: | pp. 1683-1689 |
| Identification Number: | 10.1158/1055-9965.EPI-11-0203 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| URI: | http://wrap.warwick.ac.uk/id/eprint/38562 |
Data sourced from Thomson Reuters' Web of Knowledge
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