Schmidt Andersen, Maj-Britt, Hall, Sharon A. and Dragsted, Lars Ove. (2011) Identification of European allergy patterns to the allergen families PR-10, LTP, and profilin from rosaceae fruits. Clinical Reviews in Allergy & Immunology, Vol.41 (No.1). pp. 4-19. ISSN 1080-0549

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Abstract

High fruit intakes are associated with significant health benefits but fruit allergy sufferers may be discouraged from eating fruit due to the symptoms they experience. Knowledge about allergens involved in fruit allergy and the frequent cross-reactions to other allergens is essential to (a) design the best strategy for fruit allergy testing (b) prescribe optimal avoidance diets, and (c) design technological solutions for development of hypoallergenic fruits. The objective of this review was to investigate whether some characteristic disease entities could be identified in Europe for allergy to Rosaceae fruits. Five allergy patterns were found involving the allergen families PR-10, LTP, and profilin. In the Western Mediterranean area allergies to Rosaceae fruits are caused by monosensitization to LTP, monosensitization to profilin, or co-sensitization to both these allergens. On the contrary, monosensitization to PR-10 and, to a lesser degree, co-sensitization to profilin and PR-10 is dominant in Northern and Central Europe. LTP sensitization is present both in pollinosis and non-pollinosis patients and is associated with peach allergy in particular. The disease pattern for patients sensitized to profilin is characterized by several concomitant allergies including grass and other pollens, Rosaceae and non-Rosaceae fruits. Finally, PR-10 sensitization is primarily associated to concomitant birch pollen and apple allergy.

Item Type:	Journal Article
Subjects:	Q Science > QR Microbiology > QR180 Immunology R Medicine > RC Internal medicine
Divisions:	Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH):	Allergens, Allergy -- Europe, Food allergy, Rosaceae
Journal or Publication Title:	Clinical Reviews in Allergy & Immunology
Publisher:	Humana Press, Inc.
ISSN:	1080-0549
Official Date:	August 2011
Dates:	Date Event August 2011 Published
Volume:	Vol.41
Number:	No.1
Page Range:	pp. 4-19
Identifier:	10.1007/s12016-009-8177-3
Status:	Peer Reviewed
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/38563

Data sourced from Thomson Reuters' Web of Knowledge

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