Fusar-Poli, Paolo, Crossley, Nicolas A., Woolley, J. B. (James B.), Carletti, Francesco, Perez-Iglesias, R., Broome, Matthew R., Johns, Louise C., Tabraham, Paul, Bramon, Elvira and McGuire, Philip. (2011) White matter alterations related to P300 abnormalities in individuals at high risk for psychosis : an MRI–EEG study. Journal of Psychiatry & Neuroscience, Vol.36 (No.4). pp. 239-248. ISSN 11804882

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Abstract

Background: Psychosis onset is characterized by white matter and electrophysiologic abnormalities. The relation between these factors in the development of illness is almost unknown. We studied the relation between white matter volumes and P300 in prodromal psychosis. Methods: We assessed white matter volume (detected using magnetic resonance imaging) and electrophysiologic response during an oddball task (P300) in healthy controls and individuals at high clinical risk for psychosis (with an "at-risk mental state" [ARMS]). Results: We included 41 controls and 39 patients with an ARMS in our study. A psychotic disorder developed in 26% of the ARMS group within the follow-up period of 2 years. The P300 amplitude was significantly lower in the ARMS group than in the control group. The ARMS group showed reduced volume of white matter underlying the left superior temporal gyrus and the left superior frontal gyrus and increased volume of white matter underlying the right insula and the right angular gyrus compared with controls. Relative to individuals who did not later become psychotic, the subgroup in whom psychosis subsequently developed had a smaller volume of white matter underlying the left precuneus and the right middle temporal gyrus and increased volume in the white matter underlying the right middle frontal gyrus. We observed a significant interaction in the right middle frontal gyrus: white matter volume was negatively associated with P300 amplitude in the ARMS group and positively associated with P300 amplitude in the control group. Limitations: The voxel-based morphometry method alone cannot determine whether abnormal white matter volumes are due to an altered number of axonal connections or decreased myelination. Conclusion: P300 abnormalities precede the onset of psychosis and are directly related to white matter alterations, representing a correlate of an increased vulnerability to disease.

Item Type:	Journal Article
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions:	Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Evoked potentials (Electrophysiology), Psychoses -- Pathogenesis, Schizophrenia, Meta-analysis, Electroencephalography, Magnetic resonance imaging
Journal or Publication Title:	Journal of Psychiatry & Neuroscience
Publisher:	Canadian Medical Association
ISSN:	11804882
Date:	July 2011
Volume:	Vol.36
Number:	No.4
Page Range:	pp. 239-248
Identification Number:	10.1503/jpn.100083
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
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URI:	http://wrap.warwick.ac.uk/id/eprint/38578

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