White matter alterations related to P300 abnormalities in individuals at high risk for psychosis : an MRI–EEG study
Fusar-Poli, Paolo, Crossley, Nicolas A., Woolley, J. B. (James B.), Carletti, Francesco, Perez-Iglesias, R., Broome, Matthew R., Johns, Louise C., Tabraham, Paul, Bramon, Elvira and McGuire, Philip. (2011) White matter alterations related to P300 abnormalities in individuals at high risk for psychosis : an MRI–EEG study. Journal of Psychiatry & Neuroscience, Vol.36 (No.4). pp. 239-248. ISSN 11804882Full text not available from this repository.
Official URL: http://dx.doi.org/10.1503/jpn.100083
Background: Psychosis onset is characterized by white matter and electrophysiologic abnormalities. The relation between these factors in the development of illness is almost unknown. We studied the relation between white matter volumes and P300 in prodromal psychosis. Methods: We assessed white matter volume (detected using magnetic resonance imaging) and electrophysiologic response during an oddball task (P300) in healthy controls and individuals at high clinical risk for psychosis (with an "at-risk mental state" [ARMS]). Results: We included 41 controls and 39 patients with an ARMS in our study. A psychotic disorder developed in 26% of the ARMS group within the follow-up period of 2 years. The P300 amplitude was significantly lower in the ARMS group than in the control group. The ARMS group showed reduced volume of white matter underlying the left superior temporal gyrus and the left superior frontal gyrus and increased volume of white matter underlying the right insula and the right angular gyrus compared with controls. Relative to individuals who did not later become psychotic, the subgroup in whom psychosis subsequently developed had a smaller volume of white matter underlying the left precuneus and the right middle temporal gyrus and increased volume in the white matter underlying the right middle frontal gyrus. We observed a significant interaction in the right middle frontal gyrus: white matter volume was negatively associated with P300 amplitude in the ARMS group and positively associated with P300 amplitude in the control group. Limitations: The voxel-based morphometry method alone cannot determine whether abnormal white matter volumes are due to an altered number of axonal connections or decreased myelination. Conclusion: P300 abnormalities precede the onset of psychosis and are directly related to white matter alterations, representing a correlate of an increased vulnerability to disease.
|Item Type:||Journal Article|
|Subjects:||R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
|Divisions:||Faculty of Medicine > Warwick Medical School|
|Library of Congress Subject Headings (LCSH):||Evoked potentials (Electrophysiology), Psychoses -- Pathogenesis, Schizophrenia, Meta-analysis, Electroencephalography, Magnetic resonance imaging|
|Journal or Publication Title:||Journal of Psychiatry & Neuroscience|
|Publisher:||Canadian Medical Association|
|Page Range:||pp. 239-248|
|Access rights to Published version:||Restricted or Subscription Access|
|References:||1. Jeon YW, Polich J. Meta-analysis of P300 and schizophrenia: patients, paradigms, and practical implications. Psychophysiology 2003;40:684-701. 2. Salisbury DF, Shenton ME, Sherwood AR, et al. First-episode schizophrenic psychosis differs from first-episode affective psych - osis and controls in P300 amplitude over left temporal lobe. Arch Gen Psychiatry 1998;55:173-80. 3. Umbricht DS, Bates JA, Lieberman JA, et al. Electrophysiological indices of automatic and controlled auditory information processing in first-episode, recent-onset and chronic schizophrenia. Biol Psychiatry 2006;59:762-72. 4. McCarley RW, Salisbury DF, Hirayasu Y, et al. Association between smaller left posterior superior temporal gyrus volume on magnetic resonance imaging and smaller left temporal P300 amplitude in first-episode schizophrenia. Arch Gen Psychiatry 2002;59:321-31. 5. Wang J, Hirayasu Y, Hokama H, et al. Influence of duration of untreated psychosis on auditory P300 in drug-naive and first-episode schizophrenia. Psychiatry Clin Neurosci 2005;59:209-14. 6. Van der Stelt O, Belger A. Application of electroencephalography to the study of cognitive and brain functions in schizophrenia. Schizophr Bull 2007;33:955-70. 7. Martín-Loeches M, Molina V, Munoz F, et al. P300 amplitude as a possible correlate of frontal degeneration in schizophrenia. Schizophr Res 2001;49:121-8. 8. McCarley RW, Shenton ME, O’Donnell BF, et al. Auditory P300 abnormalities and left posterior superior temporal gyrus volume reduction in schizophrenia. Arch Gen Psychiatry 1993;50:190-7. 9. Egan MF, Duncan CC, Suddath RL, et al. Event-related potential abnormalities correlate with structural brain alterations and clin - ical features in patients with chronic schizophrenia. Schizophr Res 1994;11:259-71. 10. Yung AR, Nelson B, Stanford C, et al. Validation of “prodromal” criteria to detect individuals at ultra high risk of psychosis: 2 year follow-up. Schizophr Res 2008;105:10-7. 11. Fusar-Poli P, Byrne M, Valmaggia L, et al. Social dysfunction predicts two years clinical outcome in people at ultra high risk for psychosis. J Psychiatr Res 2010;44:294-301. 12. Pukrop R, Ruhrmann S, Schultze-Lutter F, et al. Neurocognitive indicators for a conversion to psychosis: comparison of patients in a potentially initial prodromal state who did or did not convert to a psychosis. Schizophr Res 2007;92:116-25. 13. Van der Stelt O, Lieberman JA, Belger A. Auditory P300 in high-risk, recent-onset and chronic schizophrenia. Schizophr Res 2005;77:309-20. 14. Bramon E, Shaikh M, Broome M, et al. Abnormal P300 in people with high risk of developing psychosis. Neuroimage 2008;41:553-60. 15. Frommann I, Brinkmeyer J, Ruhrmann S, et al. Auditory P300 in individuals clinically at risk for psychosis. Int J Psychophysiol 2008; 70:192-205. 16. Bramon E, McDonald C, Croft RJ, et al. Is the P300 wave an endo - phenotype for schizophrenia? A meta-analysis and a family study. Neuroimage 2005;27:960-8. 17. Weisbrod M, Hill H, Niethammer R, et al. Genetic influence on auditory information processing in schizophrenia: P300 in monozygotic twins. Biol Psychiatry 1999;46:721-5. 18. Witthaus H, Kaufmann C, Bohner G, et al. Gray matter abnormal - ities in subjects at ultra-high risk for schizophrenia and first-episode schizophrenic patients compared to healthy controls. Psychiatry Res 2009;173:163-9. 19. Walterfang M, McGuire PK, Yung AR, et al. White matter volume changes in people who develop psychosis. Br J Psychiatry 2008;193: 210-5. 20. Brambilla P, Tansella M. The role of white matter for the pathophysiology of schizophrenia. Int Rev Psychiatry 2007;19:459-68. 21. Friston KJ, Frith CD. Schizophrenia: A disconnection syndrome? Clin Neurosci 1995;3:89-97. 22. Ford JM, Mathalon DH, Whitfield S, et al. Reduced communication between frontal and temporal lobes during talking in schizophrenia. Biol Psychiatry 2002;51:485-92. 23. Wolf DH, Gur RC, Valdez JN, et al. Alterations of fronto-temporal connectivity during word encoding in schizophrenia. Psychiatry Res 2007;154:221-32. 24. Wiser AK, Andreasen NC, O’Leary DS, et al. Dysfunctional corticocerebellar circuits cause ‘cognitive dysmetria’ in schizophrenia. Neuroreport 1998;9:1895-9. 25. Andreasen NC, Paradiso S, O’Leary DS. “Cognitive dysmetria” as an integrative theory of schizophrenia: A dysfunction in corticalsubcortical- cerebellar circuitry? Schizophr Bull 1998;24:203-18. 26. Crow TJ. Schizophrenia as a transcallosal misconnection syndrome. Schizophr Res 1998;30:111-4. 27. Allen P, Stephan KE, Mechelli A, et al. Cingulate activity and fronto-temporal connectivity in people with prodromal signs of psychosis. Neuroimage 2010;49:947-55. 28. Crossley NA, Mechelli A, Fusar-Poli P, et al. Superior temporal lobe dysfunction and frontotemporal dysconnectivity in subjects at risk of psychosis and in first-episode psychosis. Hum Brain Mapp 2009;30:4129-37. 29. Cardenas VA, Chao LL, Blumenfeld R, et al. Using automated morphometry to detect associations between ERP latency and structural brain MRI in normal adults. Hum Brain Mapp 2005;25:317-27. 30. Begré S, Kleinlogel H, Kiefer C, et al. White matter anisotropy related to electrophysiology of first episode schizophrenia during NoGo inhibition. Neurobiol Dis 2008;30:270-80. 31. Yung AR, Phillips LJ, McGorry PD, et al. Prediction of psychosis. A step towards indicated prevention of schizophrenia. Br J Psychiatry Suppl 1998;172:14-20. 32. Broome MR, Woolley J, Tabraham P, et al. What causes the onset of psychosis? Schizophr Res 2005;79:23-34. 33. Yung AR, Yuen HP, McGorry PD, et al. Mapping the onset of psych osis: the Comprehensive Assessment of At-Risk Mental States. Aust N Z J Psychiatry 2005;39:964-71. 34. First M, Spitzer R, Gibbon M, et al. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Non-patient Edition (SCID-I/NP). New York (NY): Biometrics Research; 2002. 35. Coren S. Measurement of handedness via self-report: the relationship between brief and extended inventories. Percept Mot Skills 1993; 76:1035-42. 36. Kay SR. Positive-negative symptom assessment in schizophrenia: psychometric issues and scale comparison. Psychiatr Q 1990;61: 163-78. 37. Nelson HE, Willison JR. National Adult Reading Test (NART). Test manual. 2nd ed. Windsor (UK): NFER-Nelson 1991. 38. Ashburner J, Friston KJ. Voxel-based morphometry — the methods. Neuroimage 2000;11:805-21. 39. Good CD, Johnsrude IS, Ashburner J, et al. A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage 2001;14:21-36. 40. Mechelli A, Friston KJ, Frackowiak RS, et al. Structural covariance in the human cortex. J Neurosci 2005;25:8303-10. 41. Fjell AM, Walhovd KB, Fischl B, et al. Cognitive function, P3a/P3b brain potentials, and cortical thickness in aging. Hum Brain Mapp 2007;28:1098-116. 42. Bramon E, Croft RJ, McDonald C, et al. Mismatch negativity in schizophrenia: a family study. Schizophr Res 2004;67:1-10. 43. Semlitsch HV, Anderer P, Schuster P, et al. A solution for reliable and valid reduction of ocular artifacts, applied to the P300 ERP. Psychophysiology 1986;23:695-703. 44. Fusar-Poli P, Perez J, Broome MR, et al. Neurofunctional correlates of liability to psychosis: a systematic review and meta-analysis. Neur Biobehav Rev 2007;31:465-84. 45. Borgwardt SJ, McGuire PK, Aston J, et al. Reductions in frontal, temporal and parietal volume associated with the onset of psych osis. Schizophr Res 2008;106:108-14. 46. Wood SJ, Pantelis C, Velakoulis D, et al. Progressive changes in the development toward schizophrenia: studies in subjects at increased symptomatic risk. Schizophr Bull 2008;34:322-9. 47. Buchsbaum MS, Tang CY, Peled S, et al. MRI white matter dif fusion anisotropy and PET metabolic rate in schizophrenia. Neuroreport 1998;9:425-30. 48. Buchsbaum MS, Friedman J, Buchsbaum BR, et al. Diffusion tensor imaging in schizophrenia. Biol Psychiatry 2006;60:1181-7. 49. Hao Y, Liu Z, Jiang T, et al. White matter integrity of the whole brain is disrupted in firstepisode schizophrenia. Neuroreport 2006; 17:23-6. 50. Schlösser RG, Nenadic I, Wagner G, et al. White matter abnormal ities and brain activation in schizophrenia: a combined DTI and fMRI study. Schizophr Res 2007;89:1-11. 51. Sun Z, Wang F, Cui L, et al. Abnormal anterior cingulum in patients with schizophrenia: a diffusion tensor imaging study. Neuroreport 2003;14:1833-6. 52. Wang F, Sun Z, Cui L, et al. Anterior cingulum abnormalities in male patients with schizophrenia determined through diffusion tensor imaging. Am J Psychiatry 2004;161:573-5. 53. Kubicki M, McCarley R, Westin CF, et al. A review of diffusion tensor imaging studies in schizophrenia. J Psychiatr Res 2007;41:15-30. 54. Ozgürdal S, Gudlowski Y, Witthaus H, et al. Reduction of auditory event-related P300 amplitude in subjects with at-risk mental state for schizophrenia. Schizophr Res 2008;105:272-8. 55. Konrad A, Winterer G. Disturbed structural connectivity in schizophrenia primary factor in pathology or epiphenomenon? Schizophr Bull 2008;34:72-92. 56. Frodl T, Meisenzahl EM, Muller D, et al. Corpus callosum and P300 in schizophrenia. Schizophr Res 2001;49:107-19. 57. Soltani M, Knight RT. Neural origins of the P300. Crit Rev Neurobiol 2000;14:199-224. 58. Linden DE. The p300: Where in the brain is it produced and what does it tell us? Neuroscientist 2005;11:563-76. 59. Menon V, Ford JM, Lim KO, et al. Combined event-related fMRI and EEG evidence for temporalparietal cortex activation during target detection. Neuroreport 1997;8:3029-37. 60. Yamaguchi S, Knight RT. Anterior and posterior association cortex contributions to the somatosensory P300. J Neurosci 1991;11:2039-54. 61. Yamaguchi S, Knight RR. Contributions of anterior and posteriorassociation cortex to the human somatosensory P3. Electroencephalogr Clin Neurophysiol Suppl 1995;44:130-9. 62. Ardekani BA, Choi SJ, Hossein-Zadeh GA, et al. Functional magnetic resonance imaging of brain activity in the visual oddball task. Brain Res Cogn Brain Res 2002;14:347-56. 63. Molina V, Sanz J, Munoz F, et al. Dorsolateral prefrontal cortex contribution to abnormalities of the P300 component of the event-related potential in schizophrenia. Psychiatry Res 2005;140:17-26. 64. Li Y, Wang LQ, Hu Y. Localizing P300 generators in high-density event-related potential with fMRI. Med Sci Monit 2009;15:MT47-53. 65. DeLisi LE. The concept of progressive brain change in schizophrenia: implications for understanding schizophrenia. Schizophr Bull 2008;34:312-21. 66. Harris JM, Whalley H, Yates S, et al. Abnormal cortical folding in high-risk individuals: A predictor of the development of schizophrenia? Biol Psychiatry 2004;56:182-9. 67. Vogeley K, Tepest R, Pfeiffer U, et al. Right frontal hypergyria differentiation in affected and unaffected siblings from families multiply affected with schizophrenia: a morphometric MRI study. Am J Psychiatry 2001;158:494-6. 68. Harris JM, Moorhead TW, Miller P, et al. Increased prefrontal gyrification in a large highrisk cohort characterizes those who develop schizophrenia and reflects abnormal prefrontal development. Biol Psychiatry 2007;62:722-9.|
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