The Library
Side-chain peptide-synthetic polymer conjugates via tandem “ester-amide/thiol–ene” post-polymerization modification of poly(pentafluorophenyl methacrylate) obtained using ATRP
Tools
Singha, Nikhil K., Gibson, Matthew I., Koiry, Bishnu P., Danial, Maarten and Klok, Harm-Anton (2011) Side-chain peptide-synthetic polymer conjugates via tandem “ester-amide/thiol–ene” post-polymerization modification of poly(pentafluorophenyl methacrylate) obtained using ATRP. Biomacromolecules, Vol.12 (No.8). pp. 2908-2913. doi:10.1021/bm200469a ISSN 1525-7797.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1021/bm200469a
Abstract
Herein the concept of tandem postpolymerization modification as a versatile route to synthesize well-defined, highly functionalized polymers is introduced. Poly(pentafluorophenyl methacrylate) obtained by atom transfer radical polymerization was first modified with allylamine, which displaces the active ester to give well-defined polymers with pendant alkene groups, which are difficult to obtain by direct (radical) polymerization of allylic-functional monomers. The produced poly(allylmethacrylamide) was modified by a second postpolymerization modification reaction with a thiol-terminated peptide (CVPGVG) using AIBN as the radical source. NMR, IR, and SEC demonstrated successful conjugation onto the polymer to give a polymer-peptide hybrid material. This versatile strategy should extend the scope of controlled radical polymerization and "click"-type reactions
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | Q Science > QD Chemistry T Technology > TP Chemical technology |
||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Polymerization, Block copolymers, Macromolecules -- Synthesis, Free radical reactions | ||||
Journal or Publication Title: | Biomacromolecules | ||||
Publisher: | American Chemical Society | ||||
ISSN: | 1525-7797 | ||||
Official Date: | August 2011 | ||||
Dates: |
|
||||
Volume: | Vol.12 | ||||
Number: | No.8 | ||||
Page Range: | pp. 2908-2913 | ||||
DOI: | 10.1021/bm200469a | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | India. Dept. of Science and Technology (DST) , École polytechnique fédérale de Lausanne (EPFL), European Union (EU) | ||||
Grant number: | INT/SWISS/RF & JUAF/2008 (DST & EPFL), NMP4-CT2006-026723 (EU) |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |