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A transcritical bifurcation in an immune response model
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Burroughs, Nigel John, Ferreira, M. (Miguel), Oliveira, Bruno M. P. M. and Pinto, Alberto A. (2011) A transcritical bifurcation in an immune response model. Journal of Difference Equations and Applications, Vol.17 (No.7). pp. 1101-1106. doi:10.1080/10236190903095291
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Official URL: http://dx.doi.org/10.1080/10236190903095291
Abstract
The consequences of regulatory T cell (Treg) inhibition of interleukine 2 secretion are examined by mathematical modelling. We find a transcritical bifurcation that might explain two alternative scenarios: in one case the appearance of autoimmune responses and in another the suppression of the immune response.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QA Mathematics Q Science > QR Microbiology > QR180 Immunology |
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| Divisions: | Faculty of Science > Mathematics Faculty of Science > Centre for Systems Biology |
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| Library of Congress Subject Headings (LCSH): | T cells, Immune response -- Mathematical models, Bifurcation theory, T cells -- Receptors, Immune response -- Regulation | ||||
| Journal or Publication Title: | Journal of Difference Equations and Applications | ||||
| Publisher: | Taylor & Francis Inc. | ||||
| ISSN: | 1023-6198 | ||||
| Official Date: | 2011 | ||||
| Dates: |
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| Volume: | Vol.17 | ||||
| Number: | No.7 | ||||
| Page Range: | pp. 1101-1106 | ||||
| DOI: | 10.1080/10236190903095291 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Funder: | Fundação para a Ciência e a Tecnologia (FCT), Portugal. Ministério da Ciência, Tecnologia e Ensino Superior (MCTES), Fundação Calouste Gulbenkian (FCG), Universidade do Minho (UdM), Universidade do Porto (UP) |
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