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A transcritical bifurcation in an immune response model

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Burroughs, Nigel John, Ferreira, M. (Miguel), Oliveira, Bruno M. P. M. and Pinto, Alberto A.. (2011) A transcritical bifurcation in an immune response model. Journal of Difference Equations and Applications, Vol.17 (No.7). pp. 1101-1106. ISSN 1023-6198

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Abstract

The consequences of regulatory T cell (Treg) inhibition of interleukine 2 secretion are examined by mathematical modelling. We find a transcritical bifurcation that might explain two alternative scenarios: in one case the appearance of autoimmune responses and in another the suppression of the immune response.

Item Type: Journal Article
Subjects: Q Science > QA Mathematics
Q Science > QR Microbiology > QR180 Immunology
Divisions: Faculty of Science > Mathematics
Faculty of Science > Centre for Systems Biology
Library of Congress Subject Headings (LCSH): T cells, Immune response -- Mathematical models, Bifurcation theory, T cells -- Receptors, Immune response -- Regulation
Journal or Publication Title: Journal of Difference Equations and Applications
Publisher: Taylor & Francis Inc.
ISSN: 1023-6198
Official Date: 2011
Volume: Vol.17
Number: No.7
Page Range: pp. 1101-1106
Identification Number: 10.1080/10236190903095291
Status: Peer Reviewed
Publication Status: Published
Funder: Fundação para a Ciência e a Tecnologia (FCT), Portugal. Ministério da Ciência, Tecnologia e Ensino Superior (MCTES), Fundação Calouste Gulbenkian (FCG), Universidade do Minho (UdM), Universidade do Porto (UP)
References:

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1106 N.J. Burroughs et al.
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URI: http://wrap.warwick.ac.uk/id/eprint/38595

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