Betanzos-Lara, Soledad, Habtemariam, Abraha, Clarkson, Guy J. and Sadler, P. J.. (2011) Organometallic cis-Dichlorido ruthenium(II) ammine complexes. European Journal of Inorganic Chemistry, Vol.2011 (No.21). pp. 3257-3264. ISSN 1434-1948

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Abstract

Bifunctional neutral half-sandwich RuII complexes of the type [(η6-arene)Ru(NH3)Cl2] where arene is p-cym (1) or bip (2) were synthesised by the reaction of N,N-dimethylbenzylamine (dmba), NH4PF6 and the corresponding RuII arene dimer, and were fully characterised. X-ray crystallographic studies of [(η6-p-cym)Ru(NH3)Cl2]·{(dmba–H)(PF6)} (1a) and [(η6-bip)Ru(NH3)Cl2] (2) show extensive H-bond interactions in the solid state, mainly involving the NH3 and the Cl ligands, as well as weak aromatic stacking interactions. The half-lives for the sequential hydrolysis of 1 and 2 determined by UV/Vis spectroscopy at 310 K ranged from a few minutes for the first aquation to ca. 45 min for the second aquation; the diaqua adducts were the predominant species at equilibrium. Arene loss during the aquation of complex 2 was observed. Upon hydrolysis, both complexes readily formed mono- and di-9-ethylguanine (9-EtG) adducts in aqueous solution at 310 K. The reaction reached equilibrium after ca. 1.8 h in the case of complex 1 and was slower but more complete for complex 2 (before the onset of arene loss at ca. 2.7 h). Complexes 1 and 2 were not cytotoxic towards A2780 human ovarian cancer cells up to the maximum concentration tested (100 μM).

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions:	Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH):	Ruthenium, Antineoplastic agents, Ligands, Cell-mediated cytotoxicity, Organometallic chemistry, Complex compounds
Journal or Publication Title:	European Journal of Inorganic Chemistry
Publisher:	Wiley-VCH Verlag GMBH
ISSN:	1434-1948
Date:	2011
Volume:	Vol.2011
Number:	No.21
Page Range:	pp. 3257-3264
Identification Number:	10.1002/ejic.201100250
Status:	Peer Reviewed
Publication Status:	Published
Funder:	The European Regional Development Fund (ERDF), European Research Council (ERC), Advantage West Midlands (AWM)
URI:	http://wrap.warwick.ac.uk/id/eprint/38672

Data sourced from Thomson Reuters' Web of Knowledge

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