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Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex
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Shnyder, Steve D., Fu, Y. (Ying), Habtemariam, Abraha, Rijt, Sabine H. van, Cooper, Patricia A., Loadman, Paul M. and Sadler, P. J. (2011) Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex. MedChemComm, Vol.2 (No.7). pp. 666-668. doi:10.1039/c1md00075f
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WRAP_Fu_467_MCC_2011_Ying Fu_2_666_deposit.pdf - Accepted Version Download (450Kb) | Preview |
Official URL: http://dx.doi.org/10.1039/c1md00075f
Abstract
This first in vivo antitumour activity for an organometallic osmium arene complex, [Os(eta(6)-p-cym)(4-(2-pyridylazo)-N,N-dimethylaniline)I]PF(6), is reported. The complex delays the growth of HCT116 human colon cancer xenografts in mice, with negligible toxicity. Its activity appears to involve redox mechanisms and its potency towards A2780 ovarian and A549 lung cancer cells is increased significantly in combination with L-buthionine-sulfoximine.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
| Library of Congress Subject Headings (LCSH): | Organometallic compounds -- Physiological effect, Antineoplastic agents -- Research, Clinical pharmacology, Colon (Anatomy) -- Cancer -- Treatment -- Research, Rectum -- Cancer -- Treatment -- Research | ||||
| Journal or Publication Title: | MedChemComm | ||||
| Publisher: | Royal Society of Chemistry | ||||
| ISSN: | 2040-2503 | ||||
| Official Date: | July 2011 | ||||
| Dates: |
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| Volume: | Vol.2 | ||||
| Number: | No.7 | ||||
| Page Range: | pp. 666-668 | ||||
| DOI: | 10.1039/c1md00075f | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Engineering and Physical Sciences Research Council (EPSRC), European Research Council (ERC), European Regional Development Fund (ERDF), Advantage West Midlands (AWM), European Union (EU) | ||||
| Grant number: | 247450 (ERC) |
Data sourced from Thomson Reuters' Web of Knowledge
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