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Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex

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Shnyder, Steve D., Fu, Y. (Ying), Habtemariam, Abraha, Rijt, Sabine H. van, Cooper, Patricia A., Loadman, Paul M. and Sadler, P. J.. (2011) Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex. MedChemComm, Vol.2 (No.7). pp. 666-668. ISSN 2040-2503

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Official URL: http://dx.doi.org/10.1039/c1md00075f

Abstract

This first in vivo antitumour activity for an organometallic osmium arene complex, [Os(eta(6)-p-cym)(4-(2-pyridylazo)-N,N-dimethylaniline)I]PF(6), is reported. The complex delays the growth of HCT116 human colon cancer xenografts in mice, with negligible toxicity. Its activity appears to involve redox mechanisms and its potency towards A2780 ovarian and A549 lung cancer cells is increased significantly in combination with L-buthionine-sulfoximine.

Item Type:

Journal Article

Subjects:

Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology

Divisions:

Faculty of Science > Chemistry

Library of Congress Subject Headings (LCSH):

Organometallic compounds -- Physiological effect, Antineoplastic agents -- Research, Clinical pharmacology, Colon (Anatomy) -- Cancer -- Treatment -- Research, Rectum -- Cancer -- Treatment -- Research

Journal or Publication Title:

MedChemComm

Publisher:

Royal Society of Chemistry

ISSN:

2040-2503

Official Date:

July 2011

Dates:

Date	Event
July 2011	Published

Volume:

Vol.2

Number:

No.7

Page Range:

pp. 666-668

Identification Number:

10.1039/c1md00075f

Status:

Peer Reviewed

Publication Status:

Published

Access rights to Published version:

Restricted or Subscription Access

Funder:

Engineering and Physical Sciences Research Council (EPSRC), European Research Council (ERC), European Regional Development Fund (ERDF), Advantage West Midlands (AWM), European Union (EU)

Grant number:

247450 (ERC)

References:

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URI:

http://wrap.warwick.ac.uk/id/eprint/38704

Data sourced from Thomson Reuters' Web of Knowledge

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