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Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex

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Shnyder, Steve D., Fu, Y. (Ying), Habtemariam, Abraha, Rijt, Sabine H. van, Cooper, Patricia A., Loadman, Paul M. and Sadler, P. J. (2011) Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex. MedChemComm, Vol.2 (No.7). pp. 666-668. doi:10.1039/c1md00075f

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Official URL: http://dx.doi.org/10.1039/c1md00075f

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Abstract

This first in vivo antitumour activity for an organometallic osmium arene complex, [Os(eta(6)-p-cym)(4-(2-pyridylazo)-N,N-dimethylaniline)I]PF(6), is reported. The complex delays the growth of HCT116 human colon cancer xenografts in mice, with negligible toxicity. Its activity appears to involve redox mechanisms and its potency towards A2780 ovarian and A549 lung cancer cells is increased significantly in combination with L-buthionine-sulfoximine.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Science, Engineering and Medicine > Science > Chemistry
Library of Congress Subject Headings (LCSH): Organometallic compounds -- Physiological effect, Antineoplastic agents -- Research, Clinical pharmacology, Colon (Anatomy) -- Cancer -- Treatment -- Research, Rectum -- Cancer -- Treatment -- Research
Journal or Publication Title: MedChemComm
Publisher: Royal Society of Chemistry
ISSN: 2040-2503
Official Date: July 2011
Dates:
DateEvent
July 2011Published
Volume: Vol.2
Number: No.7
Page Range: pp. 666-668
DOI: 10.1039/c1md00075f
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Engineering and Physical Sciences Research Council (EPSRC), European Research Council (ERC), European Regional Development Fund (ERDF), Advantage West Midlands (AWM), European Union (EU)
Grant number: 247450 (ERC)

Data sourced from Thomson Reuters' Web of Knowledge

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