Mild acetabular dysplasia and risk of osteoarthritis of the hip : a case-control study
McWilliams, Daniel F., Doherty, Sally A., Jenkins, Wendy D., Maciewicz, Rose A., Muir, Kenneth (Kenneth R.), Zhang, Weiya and Doherty, Michael, 1951-. (2010) Mild acetabular dysplasia and risk of osteoarthritis of the hip : a case-control study. Annals of the Rheumatic Diseases, Vol.69 (No.10). pp. 1774-1778. ISSN 0003-4967
WRAP_Muir_2-Ann_Rheum_Dis-2010-McWilliams-1774-8.pdf - Published Version - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Official URL: http://dx.doi.org/10.1136/ard.2009.127076
Objective To determine whether mild variation in acetabular depth (AD) and shape is a risk factor for osteoarthritis (OA) of the hip.
Methods The unaffected contralateral hip of patients with unilateral hip OA was compared with hips of asymptomatic controls without hip OA, derived from the Nottingham Genetics Osteoarthritis and Lifestyle case–control study. Standardised anteroposterior x-rays of the pelvis were used to measure centre edge (CE) angle and AD. Cut-off points for narrow CE angle and shallow AD were calculated from the control group (mean −1.96×SD). The relative risk of hip OA associated with each feature was estimated using OR and 95% CI and adjusted risks were calculated by logistic regression.
Results In controls, both the CE angle and the AD were lower in the left hip than in the right hip. The CE angle related to age in both hips, and AD of the right hip was lower in men than in women. The contralateral unaffected hip in patients with unilateral hip OA had a decreased CE angle and AD compared with controls, irrespective of side. The lowest tertile of the CE angle in contralateral hips was associated with an eightfold risk of OA (aOR 8.06, 95% CI 4.87 to 13.35) and the lowest tertile of AD was associated with a 2.5-fold risk of OA (aOR 2.53, 95% CI 1.28 to 5.00). Significant increases in the risk of OA were also found as the CE angle and AD decreased.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RC Internal medicine|
|Divisions:||Faculty of Medicine > Warwick Medical School|
|Library of Congress Subject Headings (LCSH):||Osteoarthritis -- Risk factors, Hip joint -- Diseases -- Risk factors, Hip joint -- Dislocation, Congenital|
|Journal or Publication Title:||Annals of the Rheumatic Diseases|
|Official Date:||October 2010|
|Page Range:||pp. 1774-1778|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||AstraZeneca (Firm), Arthritis Research UK|
|Grant number:||14581 (ARUK)|
1. Doherty M, Lohmander LS, Brandt KD. Osteoarthritis. 2nd edn. Oxford: Oxford
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