Isken, Frank, Abraham, U., Weickert, Martin O., Keyhani-Nejad, F., Arafat, Ayman M., Spranger, Joachim, Pfeiffer, Andreas F. H. and Möhlig, Matthias. (2011) Annual change in insulin sensitivity. Hormone and Metabolic Research, Vol.43 (No.10). pp. 720-722. ISSN 0018-5043

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Abstract

The incidence of both type 2 diabetes and cardiac events is reported to be higher during winter, indicating a putative annual periodic change in insulin sensitivity (IS). Annual differences in IS quantified as HOMA-%S and Matsuda-Sensitivity Index - were analyzed using a cosine wave-fitting algorithm in a cross-sectional study group including 2 385 participants. Additionally, semiannual differences in IS were compared. We found periodicity for HOMA-%S and Matsuda-Sensitivity Index (p = 0.02 or 0.006), which was strengthened after restriction to participants without diabetes ( p = 0.009 or 0.004). The rhythm amplitude of 0.08 indicated moderate changes in IS throughout the year. IS was significantly higher when participants were enrolled during the second vs. the first half of the year (HOMA-%S 112.0 +/- 3.0 % vs. 97.4 +/- 2.4 %, p < 0.001). The impact of the half-year on IS, which remained significant after adjustment for confounders, was again moderate and explained only 0.5% of the variation. IS showed a significant moderate annual periodicity, which may affect the interpretation of studies reporting small changes in IS.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine
Divisions:	Faculty of Medicine > Warwick Medical School > Clinical Sciences Research Institute (CSRI) Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Insulin resistance
Journal or Publication Title:	Hormone and Metabolic Research
Publisher:	Georg Thieme Verlag
ISSN:	0018-5043
Date:	September 2011
Volume:	Vol.43
Number:	No.10
Number of Pages:	3
Page Range:	pp. 720-722
Identification Number:	10.1055/s-0031-1286310
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Deutsche Forschungsgemeinschaft (DFG), [Federal Germany. Bundesministerium für Bildung und Forschung (BMBF)
Grant number:	PF 164/14-2 (DFG), KFO218/1 (DFG), AB 139/4-1 (DFG), GK 1208 (DFG), SP716/2-1 (HP)
URI:	http://wrap.warwick.ac.uk/id/eprint/38745

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