Sperm motility : is viscosity fundamental to progress?
Kirkman-Brown, J. C. and Smith, D. J. (David J.). (2011) Sperm motility : is viscosity fundamental to progress? Molecular Human Reproduction, Vol.17 (No.8). pp. 539-544. ISSN 1360-9947Full text not available from this repository.
Official URL: http://dx.doi.org/10.1093/molehr/gar043
The success of internal fertilization is reliant upon successful sperm migration through the female tract. Timely location of the oocyte in what is a complex three-dimensional, highly invaginated series of moist opposed surfaces is a challenge at which only tens of sperm ever succeed. In part this could be due to the differences in scale, with a 50 mm long cell facing a probable migration of well over 20 cm due to the complex architecture. Many groups have focused upon the role for a chemotactic 'attractive egg' effect in guiding sperm to increase numbers at the fertilization site. What most research has neglected to consider is the role that the viscosity of the mucous layers, which coat the entire tract and through which sperm must swim, plays in both sperm selection and ongoing modulation of their behaviour. From allowing sperm to enter through the cervix during the ovulation phase, to denying them entrance through action of the female contraceptive pill, viscous effects are fundamental in controlling the migrating sperm population throughout the tract. The physiological effects of viscosity are also crucial to consider when designing and extrapolating data from in vitro experiments to the in vivo situation.
|Item Type:||Journal Article|
|Subjects:||Q Science > QA Mathematics
Q Science > QC Physics
Q Science > QP Physiology
|Divisions:||Faculty of Science > Computer Science
Faculty of Science > Engineering
Faculty of Science > Mathematics
|Library of Congress Subject Headings (LCSH):||Spermatozoa -- Motility -- Research, Viscosity, Cervix mucus, Flagella (Microbiology), Fertilization (Biology), Fluid mechanics|
|Journal or Publication Title:||Molecular Human Reproduction|
|Publisher:||Oxford University Press|
|Page Range:||pp. 539-544|
|Funder:||Birmingham Science City , Wellcome Trust (London, England), Medical Research Council (Great Britain) (MRC), Science and Technology Facilities Council (Great Britain) (STFC)|
|Grant number:||G0600178 (MRC), ST/G00451X/1 (STFC)|
|References:||Aitken RJ, Bowie H, Buckingham D, Harkiss D, Richardson DW, West KM. Sperm penetration into a hyaluronic acid polymer as a means of monitoring functional competance. J Androl 1992;13:44–54. Assou S, Haouzi D, De Vos J, Hamamah S. Human cumulus cells as biomarkers for embryo and pregnancy outcomes. Mol Hum Reprod 2010;16:531–8. Avile´s M, Gutie´rrez-Ada´n A, Coy P. Oviductal secretions: will they be key factors for the future ARTs? Mol Hum Reprod 2010;16:896–906. Bahat A, Eisenbach M. Sperm thermotaxis. Mol Cell Endocrinol 2006; 252:115–9. Bahat A, Eisenbach M. Human sperm thermotaxis is mediated by phospholipase C and inositol trisphosphate receptor Ca2+ channel. Biol Reprod 2010;82:606–16. Bahat A, Tur-Kaspa I, Gakamsky A, Giojalas LC, Breitbart H, Eisenbach M. Thermotaxis of mammalian sperm cells: a potential navigation mechanism in the female genital tract. Nat Med 2003;9:149–50. Bjo¨rndahl L. The usefulness and significance of assessing rapidly progressive spermatozoa. Asian J Androl 2010;12:33–5. Bjo¨rndahl L, Kvist U. Human sperm chromatin stabilization: a proposed model including zinc bridges. Mol Hum Reprod 2010;16:23–9. Bjo¨rndahl L, Kirkman-Brown J, Hart G, Rattle S, Barratt CL. Development of a novel home sperm test. Hum Reprod 2006;21:145–9. Bo¨ nigk W, Loogen A, Seifert R, Kashikar N, Klemm C, Krause E, Hagen V, Kremmer E, Stru¨nker T, Kaupp UB. An atypical CNG channel activated by a single cGMP molecule controls sperm chemotaxis. Sci Signal 2009; 2:ra68. Brokaw CJ. Effects of increased viscosity on the movements of some invertebrate spermatozoa. J Exp Biol 1966;45:113–39. Brokaw CJ. Effects of viscosity and ATP concentration on the movement of reactivated sea-urchin sperm flagella. J Exp Biol 1975;62:701–719. Brokaw CJ. Computer simulation of flagellar movement VIII: Coordination of dynein by local curvature control can generate helical bending waves. Cell Motil Cytoskelet 2002;53:103–24. Check JH, Adelson HG, Wu CH. Improvement of cervical factor with guaifenesin. Fertil Steril 1982;37:707–8. Cooper TG, Woolley DM. Stroboscopic illumination for the assessment of hyperactivated motility of mouse spermatozoa. J Exp Zool 1982; 223:291–4. Cosson J, Huitorel P, Gagnon C. How spermatozoa come to be confined to surfaces. Cell Motil. Cytoskelet 2003;54:56–63. Fauci LJ, McDonald A. Sperm motility in the presence of boundaries. Bull Math Biol 1995;57:679–99. Ford WCL. Glycolysis and sperm motility Does a spoonful of sugar help the flagellum go round? Hum. Reprod Update 2006;112:269–74. Gadelha H., Gaffney E. A., Smith D. J., Kirkman-Brown J. C. Non-linear instability in flagellar dynamics: A novel modulation mechanism in sperm migration? J Roy Soc Interface 2010;7:1689. Gaffney E. A., Gadelha H, Smith DJ, Blake JR, Kirkman-Brown JC. Mammalian sperm motility observation and theory. Annu Rev Fluid Mechanics 2011;43:p501–528. Gray J, Hancock GJ. The propulsion of sea urchin spermatozoa. J Exp Biol 1955;32:802–14. Hunter RH. Sperm release from oviduct epithelial binding is controlled hormonally by peri-ovulatory graafian follicles. Mol Reprod Dev 2008; 75:167–74. Ishijima S, Oshio S, Mohri H. Flagellar movement of human spermatozoa. Gamete Res 1986;13:185–197. Jaiswal BS, Tur-Kaspa I, Dor J, Mashiach S, Eisenbach M. Human sperm chemotaxis: is progesterone a chemoattractant? Biol Reprod 1999; 60:1314–9. Jansen RP. Cyclic changes in the human fallopian tube isthmus and their functional importance. Am J Obstet Gynecol 1980;136: 292–308. Katz DF, Mills RN, Pritchett TR. The movement of human spermatozoa in cervical mucus. J Reprod Fertil 1978;53:259–65. Kido A, Togashi K, Kataoka ML, Nakai A, Koyama T, Fujii S. Intrauterine devices and uterine peristalsis: evaluation with MRI. Magn Reson Imaging 2008;26:54–8. Kilic F, Kashikar ND, Schmidt R, Alvarez L, Dai L, Weyand I, Wiesner B, Goodwin N, Hagen V, Kaupp UB. Caged progesterone: a new tool for studying rapid nongenomic actions of progesterone. J Am Chem Soc 2009;131:4027–30. Kremer J. A simple sperm penetration test. Int J Fertil 1965;10:209–15. Kremer J, Jager S. The sperm-cervical mucus contact test a preliminary report. Fertil Steril 1976;27:335–40. Lazebnik Y. Can a biologist fix a radio?–Or, what I learned while studying apoptosis. Cancer Cell 2002;2:179–82. Lindemann CB, Leisch KA. Flagellar and ciliary beating the proven and the possible. J Cell Sci 2010;123:519–28. Lishko PV, Botchkina IL, Kirichok Y. Progesterone activates the principal Ca2+ channel of human sperm. Nature 2011;471:387–91. Mills RN, Katz DF. A flat capillary tube system for assessment of sperm movement in cervical mucus. Fertil Steril 1978;29:43–7. Mortimer D, Mortimer ST, Shu MA, Swart R. A simplified approach to sperm-cervical mucus interaction testing using a hyaluronate migration test. Hum Reprod 1990;5:835–841. Ola B, Afnan M, Papaioannou S, Sharif K, Bjo¨ rndahl L, Coomarasamy A. Accuracy of sperm-cervical mucus penetration tests in evaluating sperm motility in semen: a systematic quantitative review. Hum Reprod 2003;18:1037–46. Pate EF, Brokaw CJ. Movement of spermatozoa in viscous environments. J Exp Biol 1980;88:395–7. Pelle DW, Brokaw CJ, Lesich KA, Lindemann CB. Mechanical properties of the passive sea urchin sperm flagellum. Cell Motil Cytoskelet 2009; 66:721–35. Purcell E. M. Life at low Reynolds number. Am J Phys 1977;45:3–11. Rikmenspoel R. Movements and active moments of bull sperm flagella as a function of temperature and viscosity. J Exp Biol 1984;108:205–30. Rothschild L. Non-random distribution of bull spermatozoa in a drop of sperm suspension. Nature 1963;198:1221–22. Smith DJ, Blake JR. Surface accumulation of spermatozoa: a fluid dynamic phenomenon. Math Sci 2009;34:74–87. Smith DJ, Gaffney EA, Blake JR, Kirkman-Brown JC. Human sperm accumulation near surfaces: a simulation study. J Fluid Mech 2009a; 621:289–320. Smith DJ, Gaffney EA, Gadheˆla H, Kapur N, Kirkman-Brown JC. Bend propagation in the flagella of migrating human sperm, and its modulation by viscosity. Cell Motil Cytoskelet 2009b;66:220–36. Smith DJ, Gaffney EA, Shum H, Gadheˆla H, Kirkman-Brown JC. Comment to the article ‘Hydrodynamics of sperm at surfaces by Elgeti, Kaupp & Gompper. Biophys. J 2011;100:2318–20. Spehr M, Gisselmann G, Poplawski A, Riffell JA, Wetzel CH, Zimmer RK, Hatt H. Identification of a testicular odorant receptor mediating human sperm chemotaxis. Science 2003;299:2054–8. Spehr M, Schwane K, Riffell JA, Barbour J, Zimmer RK, Neuhaus EM, Hatt H. Particulate adenylate cyclase plays a key role in human sperm olfactory receptor-mediated chemotaxis. J Biol Chem 2004; 279:40194–203. Spehr M, Schwane K, Riffell JA, Zimmer RK, Hatt H. Odorant receptors and olfactory-like signaling mechanisms in mammalian sperm. Mol Cell Endocrinol 2006;250:128–36. Storey BT. Mammalian spermmetabolism oxygen and sugar, friend and foe. Int J Dev Biol 2008;52:427–37. Stru¨nker T, Goodwin N, Brenker C, Kashikar ND, Weyand I, Seifert R, Kaupp UB. The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm. Nature 2011;471:382–6. Suarez SS, Dai XB. Hyperactivation enhances mouse sperm capacity for penetrating viscoelastic media. Biol Reprod 1992;46:686–691. Taylor GI. Low Reynolds Number Flow. US National Committee for Fluid Mechanics Films 1967 (Except from 26:20–28:50) URL: http:// modular.mit.edu:8080/ramgen/ifluids/Low_Reynolds_Number_Flow. rm (17 February 2011, date last accessed). Teves ME, Barbano F, Guidobaldi HA, Sanchez R, Miska W, Giojalas LC. Progesterone at the picomolar range is a chemoattractant for mammalian spermatozoa. Fertil Steril 2006;86:745–9. Teves ME, Guidobaldi HA, Un˜ates DR, Sanchez R, MiskaW, Publicover SJ, Morales Garcia AA, Giojalas LC. Molecular mechanism for human sperm chemotaxis mediated by progesterone. PLoS One 2009;4:e8211. Veitinger T, Riffell JR, Veitinger S, Nascimento JM, Triller A, Chandsawangbhuwana C, Schwane K, Geerts A, Wunder F, Berns MW et al. Chemosensory Ca2+ dynamics correlate with diverse behavioural phenotypes in human sperm. J Biol Chem 2011;286:17311–25. Vizza E, Muglia U, Macchiarelli G, Baschieri L, Pasetto N, Motta PM. Three-dimensional architecture of the human myosalpinx isthmus. Scanning electron microscopy after NaOH digestion and ultrasonic microdissection. Cell Tissue Res 1991;266:219–21. Wolf DP, Blasco L, Khan MA, Litt M. Human cervical mucus. II. Changes in viscoelasticity during the menstral cycle. Fertil Steril 1977;28:47–52. Woolley DM. Evidence for ‘twisted plane’ undulations in golden hamster sperm tails. J Cell Biol 1977;75:851–65. Woolley DM. A method for determining the three-dimensional form of active flagella, using two-colour darkground illumination. J Microsc 1981;121:241–4. Woolley DM. Motility of spermatozoa at surfaces. Reproduction 2003; 126:259–70. Woolley D. M. Flagellar oscillation: a commentary on proposed mechanisms. Biol Rev 2010;85:453–470. doi:10.1111/j.1469-185X. 2009.00110.x Woolley DM, Vernon GG. A study of helical and planar waves on sea urchin sperm flagella, with a theory of how they are generated. J Exp Biol 2001;204:1333–45. Woolley D M., Crockett RF., Groom W D. I., Revell G. A study of synchronisation between the flagella of bull spermatozoa, with related observations. J Exp Biol 2009;212:2215–2223. Yeung CH, Woolley DM. A study of bend formation in locally reactivated hamster sperm flagella. J Muscle Res Cell Motil 1983;4:625–45. Yeung CH, Woolley DM. Three-dimensional bend propagation in hamster sperm models and the direction of roll in free-swimming cells. Cell Motil 1984;4:215–26|
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