Roper, Marcus, Ellison, Chris, Taylor, John W. and Glass, N. Louise. (2011) Nuclear and Genome Dynamics in Multinucleate Ascomycete Fungi. Current Biology, Vol.21 (No.18). R786-R793. ISSN 0960-9822

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Abstract

Genetic variation between individuals is essential to evolution and adaptation. However, intra-organismic genetic variation also shapes the life histories of many organisms, including filamentous fungi. A single fungal syncytium can harbor thousands or millions of mobile and potentially genotypically different nuclei, each having the capacity to regenerate a new organism. Because the dispersal of asexual or sexual spores propagates individual nuclei in many of these species, selection acting at the level of nuclei creates the potential for competitive and cooperative genome dynamics. Recent work in Neurospora crassa and Sclerotinia sclerotiorum has illuminated how nuclear populations are coordinated for fungal growth and other behaviors and has revealed both molecular and physical mechanisms for preventing and policing inter-genomic conflict. Recent results from population-level genomic studies in a variety of filamentous fungi suggest that nuclear exchange between mycelia and recombination between heterospecific nuclei may be of more importance to fungal evolution, diversity and the emergence of newly virulent strains than has previously been recognized.

Item Type:	Journal Article
Subjects:	Q Science > QA Mathematics
Journal or Publication Title:	Current Biology
Publisher:	Cell Press
ISSN:	0960-9822
Date:	2011
Volume:	Vol.21
Number:	No.18
Number of Pages:	8
Page Range:	R786-R793
Identification Number:	10.1016/j.cub.2011.06.042
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Miller Institute for Basic Research in Sciences, National Science Foundation , National Institutes of Health
Grant number:	MCB0817615 (NSF), R24GM081597 (NIH)
URI:	http://wrap.warwick.ac.uk/id/eprint/39262

Data sourced from Thomson Reuters' Web of Knowledge

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