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How many conformations can a protein remember?

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Fink, Thomas M. A. and Ball, Robin (2001) How many conformations can a protein remember? Physical Review Letters, Vol.87 (No.19). Article 198103 . doi:10.1103/PhysRevLett.87.198103 ISSN 0031-9007.

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Official URL: http://dx.doi.org/10.1103/PhysRevLett.87.198103

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Abstract

We show that a protein can be trained to recognize multiple conformations, analogous to an associative memory, and provide capacity calculations based on energy fluctuations and information theory. Unlike the linear capacity of a Hopfield network, the number of conformations which can be remembered by a protein sequence depends on the size of the amino acid alphabet as lnA, independent of protein length. This admits the possibility of certain proteins, such as prions, evolving to fold to independent stable conformations, as well as novel possibilities for protein and heteropolymer design.

Item Type: Journal Article
Subjects: Q Science > QC Physics
Q Science > QP Physiology
Divisions: Faculty of Science, Engineering and Medicine > Science > Physics
Library of Congress Subject Headings (LCSH): Proteins -- Conformation
Journal or Publication Title: Physical Review Letters
Publisher: American Physical Society
ISSN: 0031-9007
Official Date: 2001
Dates:
DateEvent
2001Published
Volume: Vol.87
Number: No.19
Number of Pages: 4
Page Range: Article 198103
DOI: 10.1103/PhysRevLett.87.198103
Status: Peer Reviewed
Publication Status: Published

Data sourced from Thomson Reuters' Web of Knowledge

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