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How many conformations can a protein remember?
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Fink, Thomas M. A. and Ball, Robin (2001) How many conformations can a protein remember? Physical Review Letters, Vol.87 (No.19). Article 198103 . doi:10.1103/PhysRevLett.87.198103
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Official URL: http://dx.doi.org/10.1103/PhysRevLett.87.198103
Abstract
We show that a protein can be trained to recognize multiple conformations, analogous to an associative memory, and provide capacity calculations based on energy fluctuations and information theory. Unlike the linear capacity of a Hopfield network, the number of conformations which can be remembered by a protein sequence depends on the size of the amino acid alphabet as lnA, independent of protein length. This admits the possibility of certain proteins, such as prions, evolving to fold to independent stable conformations, as well as novel possibilities for protein and heteropolymer design.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QC Physics Q Science > QP Physiology |
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| Divisions: | Faculty of Science > Physics | ||||
| Library of Congress Subject Headings (LCSH): | Proteins -- Conformation | ||||
| Journal or Publication Title: | Physical Review Letters | ||||
| Publisher: | American Physical Society | ||||
| ISSN: | 0031-9007 | ||||
| Official Date: | 2001 | ||||
| Dates: |
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| Volume: | Vol.87 | ||||
| Number: | No.19 | ||||
| Number of Pages: | 4 | ||||
| Page Range: | Article 198103 | ||||
| DOI: | 10.1103/PhysRevLett.87.198103 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published |
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