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Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor-2 inhibits type 1 interferon signalling by targeting interferon-stimulated gene factor-3
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Mutocheluh, M., Hindle, L., Areste, C., Chanas, S. A., Butler, L. M., Lowry, Kym, Shah, K., Evans, David J. and Blackbourn, D. J. (2011) Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor-2 inhibits type 1 interferon signalling by targeting interferon-stimulated gene factor-3. Journal of General Virology, 92 (10). pp. 2394-2398. doi:10.1099/vir.0.034322-0 ISSN 0022-1317.
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Official URL: http://dx.doi.org/10.1099/vir.0.034322-0
Abstract
Kaposi's sarcoma-associated herpesvirus (KSHV) encodes four viral interferon regulatory factors (vIRF-1-4). We investigated the mechanism and consequences of vIRF-2-mediated inhibition of interferon-response element signalling following type 1 interferon (IFN) induction. Western blot and electrophoretic mobility-shift assays identified the interferon-stimulated gene factor-3 (ISGF-3) components STAT1 and IRF-9 as the proximal targets of vIRF-2 activity. The biological significance of vIRF-2 inhibition of ISGF-3 was demonstrated by vIRF-2-mediated rescue of the replication of the IFN-sensitive virus encephalomyocarditis virus. This study provides both a mechanism and evidence for KSHV vIRF-2-mediated suppression of the consequences of type 1 IFN-induced signalling.
Item Type: | Journal Article | ||||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||
Journal or Publication Title: | Journal of General Virology | ||||||||||
Publisher: | Society for General Microbiology | ||||||||||
ISSN: | 0022-1317 | ||||||||||
Official Date: | 1 October 2011 | ||||||||||
Dates: |
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Volume: | 92 | ||||||||||
Number: | 10 | ||||||||||
Number of Pages: | 5 | ||||||||||
Page Range: | pp. 2394-2398 | ||||||||||
DOI: | 10.1099/vir.0.034322-0 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||
Funder: | Cancer Research UK (CRUK), Medical Research Council (Great Britain) (MRC), Government of Ghana Education Trust, University of Warwick | ||||||||||
Grant number: | C7934, G0800154, G0400408 |
Data sourced from Thomson Reuters' Web of Knowledge
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