Slavin, Stacy, Khoshdel, Ezat and Haddleton, David M. (2011) PEGylation of surface protein filaments: coverage and impact on denaturation. RSC Advances , Vol.1 (No.1). pp. 58-66. doi:10.1039/c1ra00157d

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Abstract

N-Hydroxysuccinimidyl functional polymers for multi-site bioconjugation to amine residues present in α-keratin protein filaments were synthesised via living radical polymerisation. Monomers containing di(ethylene glycol) and poly(ethylene glycol) were employed to give water soluble polymers which were characterised using 1H NMR and size exclusion chromatography (SEC). The denaturation temperature of the PEG–keratin conjugates was examined using differential scanning calorimetry (DSC) to show that after conjugation to damaged keratinous material, the structural properties of the protein were improved against thermal degradation. Scanning electron microscopy was used to visualise surface coverage.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry
Divisions:	Faculty of Science > Chemistry
Journal or Publication Title:	RSC Advances
Publisher:	Royal Society of Chemistry
ISSN:	2046-2069
Official Date:	2011
Dates:	Date Event 2011 Published
Volume:	Vol.1
Number:	No.1
Number of Pages:	9
Page Range:	pp. 58-66
DOI:	10.1039/c1ra00157d
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Engineering and Physical Sciences Research Council (EPSRC), Unilever PLC, European Regional Development Fund (ERDF)

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