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Ricin trafficking in plant and mammalian cells
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Lord, Mike (J. Mike) and Spooner, Robert A.. (2011) Ricin trafficking in plant and mammalian cells. Toxins, Vol.3 (No.7). pp. 787-801. ISSN 2072-6651
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Official URL: http://dx.doi.org/10.3390/toxins3070787
Abstract
Ricin is a heterodimeric plant protein that is potently toxic to mammalian and many other eukaryotic cells. It is synthesized and stored in the endosperm cells of maturing Ricinus communis seeds (castor beans). The ricin family has two major members, both, lectins, collectively known as Ricinus communis agglutinin ll (ricin) and Ricinus communis agglutinin l (RCA). These proteins are stored in vacuoles within the endosperm cells of mature Ricinus seeds and they are rapidly broken down by hydrolysis during the early stages of post-germinative growth. Both ricin and RCA traffic within the plant cell from their site of synthesis to the storage vacuoles, and when they intoxicate mammalian cells they traffic from outside the cell to their site of action. In this review we will consider both of these trafficking routes.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Science > Life Sciences (2010- ) |
| Library of Congress Subject Headings (LCSH): | Ricin -- Synthesis, Cells, Endoplasmic reticulum |
| Journal or Publication Title: | Toxins |
| Publisher: | MDPI Publishing |
| ISSN: | 2072-6651 |
| Date: | 2011 |
| Volume: | Vol.3 |
| Number: | No.7 |
| Page Range: | pp. 787-801 |
| Identification Number: | 10.3390/toxins3070787 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| URI: | http://wrap.warwick.ac.uk/id/eprint/39733 |
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