Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Ricin trafficking in plant and mammalian cells

Tools
- Tools
+ Tools

Lord, Mike and Spooner, Robert A. (2011) Ricin trafficking in plant and mammalian cells. Toxins, Volume 3 (Number 7). pp. 787-801. doi:10.3390/toxins3070787 ISSN 2072-6651.

[img]
Preview
PDF
WRAP_toxins-03-00787.pdf - Published Version - Requires a PDF viewer.
Available under License Creative Commons Attribution.

Download (558Kb) | Preview
Official URL: http://dx.doi.org/10.3390/toxins3070787

Request Changes to record.

Abstract

Ricin is a heterodimeric plant protein that is potently toxic to mammalian and many other eukaryotic cells. It is synthesized and stored in the endosperm cells of maturing Ricinus communis seeds (castor beans). The ricin family has two major members, both, lectins, collectively known as Ricinus communis agglutinin ll (ricin) and Ricinus communis agglutinin l (RCA). These proteins are stored in vacuoles within the endosperm cells of mature Ricinus seeds and they are rapidly broken down by hydrolysis during the early stages of post-germinative growth. Both ricin and RCA traffic within the plant cell from their site of synthesis to the storage vacuoles, and when they intoxicate mammalian cells they traffic from outside the cell to their site of action. In this review we will consider both of these trafficking routes.

Item Type: Journal Article
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Ricin -- Synthesis, Cells, Endoplasmic reticulum
Journal or Publication Title: Toxins
Publisher: MDPI Publishing
ISSN: 2072-6651
Official Date: 30 June 2011
Dates:
DateEvent
30 June 2011Published
23 June 2011Accepted
18 May 2011Submitted
Volume: Volume 3
Number: Number 7
Page Range: pp. 787-801
DOI: 10.3390/toxins3070787
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 18 December 2015
Date of first compliant Open Access: 18 December 2015

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us