Lord, Mike (J. Mike) and Spooner, Robert A.. (2011) Ricin trafficking in plant and mammalian cells. Toxins, Vol.3 (No.7). pp. 787-801. ISSN 2072-6651

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Abstract

Ricin is a heterodimeric plant protein that is potently toxic to mammalian and many other eukaryotic cells. It is synthesized and stored in the endosperm cells of maturing Ricinus communis seeds (castor beans). The ricin family has two major members, both, lectins, collectively known as Ricinus communis agglutinin ll (ricin) and Ricinus communis agglutinin l (RCA). These proteins are stored in vacuoles within the endosperm cells of mature Ricinus seeds and they are rapidly broken down by hydrolysis during the early stages of post-germinative growth. Both ricin and RCA traffic within the plant cell from their site of synthesis to the storage vacuoles, and when they intoxicate mammalian cells they traffic from outside the cell to their site of action. In this review we will consider both of these trafficking routes.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH301 Biology
Divisions:	Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH):	Ricin -- Synthesis, Cells, Endoplasmic reticulum
Journal or Publication Title:	Toxins
Publisher:	MDPI Publishing
ISSN:	2072-6651
Date:	2011
Volume:	Vol.3
Number:	No.7
Page Range:	pp. 787-801
Identification Number:	10.3390/toxins3070787
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/39733

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