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Autoimmunity arising from bystander proliferation of T cells in an immune response model
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Burroughs, Nigel John, Ferreira, M. (Miguel), Oliveira, B. M. P. M. and Pinto, Alberto A. (2011) Autoimmunity arising from bystander proliferation of T cells in an immune response model. Mathematical and Computer Modelling, Volume 53 (Numbers 7-8). pp. 1389-1393. doi:10.1016/j.mcm.2010.01.020 ISSN 0895-7177.
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Official URL: http://dx.doi.org/10.1016/j.mcm.2010.01.020
Abstract
We study a mathematical model of immune response by T cells where the regulatory T cells (Treg) inhibit interleukin 2 secretion. The bystander proliferation to an immune response is modelled. We consider an asymmetry reflecting that the difference between the growth and death rates can be higher for the active T cells and Tregs than for the inactive. This asymmetry leads to a better understanding of the bystander proliferation. An exposure to a pathogen results in an increased proliferation rate of the bystander T cells. If the population of the bystander T cells becomes large enough, autoimmunity can arise, eventually after a long transient period. (C) 2010 Elsevier Ltd. All rights reserved.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QA Mathematics Q Science > QR Microbiology > QR180 Immunology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Mathematics | ||||
| Library of Congress Subject Headings (LCSH): | Immune response -- Mathematical models, T cells, Cytokines | ||||
| Journal or Publication Title: | Mathematical and Computer Modelling | ||||
| Publisher: | Pergamon | ||||
| ISSN: | 0895-7177 | ||||
| Official Date: | April 2011 | ||||
| Dates: |
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| Volume: | Volume 53 | ||||
| Number: | Numbers 7-8 | ||||
| Page Range: | pp. 1389-1393 | ||||
| DOI: | 10.1016/j.mcm.2010.01.020 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Funder: | Fundação para a Ciência e a Tecnologia (FCT), Ministerio da Ciencia, Tecnologia e do Ensino Superior, Calouste Gulbenkian Foundation , Universidade do Minho (UdM), Universidade do Porto, European Social Fund (ESF), European Union (EU) |
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