Autoimmunity arising from bystander proliferation of T cells in an immune response model
Burroughs, Nigel John, Ferreira, M. (Miguel), Oliveira, B. M. P. M. and Pinto, Alberto A.. (2011) Autoimmunity arising from bystander proliferation of T cells in an immune response model. Mathematical and Computer Modelling, Volume 53 (Numbers 7-8). pp. 1389-1393. ISSN 0895-7177Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.mcm.2010.01.020
We study a mathematical model of immune response by T cells where the regulatory T cells (Treg) inhibit interleukin 2 secretion. The bystander proliferation to an immune response is modelled. We consider an asymmetry reflecting that the difference between the growth and death rates can be higher for the active T cells and Tregs than for the inactive. This asymmetry leads to a better understanding of the bystander proliferation. An exposure to a pathogen results in an increased proliferation rate of the bystander T cells. If the population of the bystander T cells becomes large enough, autoimmunity can arise, eventually after a long transient period. (C) 2010 Elsevier Ltd. All rights reserved.
|Item Type:||Journal Article|
|Subjects:||Q Science > QA Mathematics
Q Science > QR Microbiology > QR180 Immunology
|Divisions:||Faculty of Science > Mathematics|
|Library of Congress Subject Headings (LCSH):||Immune response -- Mathematical models, T cells, Cytokines|
|Journal or Publication Title:||Mathematical and Computer Modelling|
|Official Date:||April 2011|
|Page Range:||pp. 1389-1393|
|Funder:||Fundação para a Ciência e a Tecnologia (FCT), Ministerio da Ciencia, Tecnologia e do Ensino Superior, Calouste Gulbenkian Foundation , Universidade do Minho (UdM), Universidade do Porto, European Social Fund (ESF), European Union (EU)|
 E.M. Shevach, R.S. McHugh, C.A. Piccirillo, A.M. Thornton, Control of T-cell activation by CD4(+)CD25(+) suppressor T cells, Immunological Rev. 182
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