The Library

Autoimmunity arising from bystander proliferation of T cells in an immune response model

Tools

Burroughs, Nigel John, Ferreira, M. (Miguel), Oliveira, B. M. P. M. and Pinto, Alberto A.. (2011) Autoimmunity arising from bystander proliferation of T cells in an immune response model. Mathematical and Computer Modelling, Volume 53 (Numbers 7-8). pp. 1389-1393. ISSN 0895-7177

Full text not available from this repository.

Official URL: http://dx.doi.org/10.1016/j.mcm.2010.01.020

Abstract

We study a mathematical model of immune response by T cells where the regulatory T cells (Treg) inhibit interleukin 2 secretion. The bystander proliferation to an immune response is modelled. We consider an asymmetry reflecting that the difference between the growth and death rates can be higher for the active T cells and Tregs than for the inactive. This asymmetry leads to a better understanding of the bystander proliferation. An exposure to a pathogen results in an increased proliferation rate of the bystander T cells. If the population of the bystander T cells becomes large enough, autoimmunity can arise, eventually after a long transient period. (C) 2010 Elsevier Ltd. All rights reserved.

Item Type:

Journal Article

Subjects:

Q Science > QA Mathematics
Q Science > QR Microbiology > QR180 Immunology

Divisions:

Faculty of Science > Mathematics

Library of Congress Subject Headings (LCSH):

Immune response -- Mathematical models, T cells, Cytokines

Journal or Publication Title:

Mathematical and Computer Modelling

Publisher:

Pergamon

ISSN:

0895-7177

Official Date:

April 2011

Dates:

Date	Event
April 2011	Published

Volume:

Volume 53

Number:

Numbers 7-8

Page Range:

pp. 1389-1393

Identification Number:

10.1016/j.mcm.2010.01.020

Status:

Peer Reviewed

Publication Status:

Published

Funder:

Fundação para a Ciência e a Tecnologia (FCT), Ministerio da Ciencia, Tecnologia e do Ensino Superior, Calouste Gulbenkian Foundation , Universidade do Minho (UdM), Universidade do Porto, European Social Fund (ESF), European Union (EU)

References:

[1] E.M. Shevach, R.S. McHugh, C.A. Piccirillo, A.M. Thornton, Control of T-cell activation by CD4(+)CD25(+) suppressor T cells, Immunological Rev. 182
(2001) 58–67.
[2] A.M. Thornton, E.M. Shevach, CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukine 2
production, J. Exp. Med. 188 (1998) 287–296.
[3] N.J. Burroughs, B.M.P.M. Oliveira, A.A. Pinto, Regulatory T cell adjustment of quorum growth thresholds and the control of local immune responses,
J. Theoret. Biol. 241 (2006) 134–141.
[4] N.J. Burroughs, B.M.P.M. Oliveira, A.A. Pinto, H.J.T. Sequeira, Sensibility of the quorum growth thresholds controlling local immune responses, Math.
Comput. Modelling 47 (2008) 714–725.
[5] N.J. Burroughs, B.M.P.M. Oliveira, A.A. Pinto, M. Ferreira, A transcritical bifurcation in an immune response model, J. Difference Equ. Appl. (in press).
[6] A.R. McLean, Modelling T cell memory, J. Theoret. Biol. (1994) 63–74.
[7] C. Utzny, N.J. Burroughs, Perturbation theory analysis of competition in a heterogeneous population, Physica D 175 (2003) 109–126.
[8] R.J. de Boer, P. Hogeweg, Immunological discrimination between self and non-self by precursor depletion and memory accumulation, J. Theoret. Biol.
124 (1987) 343.
[9] K. Leon, A. Lage, J. Carneiro, Tolerance and immunity in a mathematical model of T-cell mediated suppression, J. Theoret. Biol. 225 (2003) 107–126.
[10] K. Leon, R. Perez, A. Lage, J. Carneiro, Modelling T-cell-mediated suppression dependent on interactions in multicellular conjugates, J. Theoret. Biol.
207 (2000) 231–254.
[11] S. Sakaguchi, Naturally arising CD4+ regulatory T cells for immunological self-tolerance and negative control of immune responses, Annu. Rev.
Immunol. 22 (2004) 531–562.
[12] A.M. Thornton, E.E. Donovan, C.A. Piccirillo, E.M. Shevach, Cutting edge: IL-2 is critically required for the in vitro activation of CD4(+)CD25(+) T cell
suppressor function, J. Immunol. 172 (2004) 6519–6523.
[13] Robin E. Callard, Jaroslav Stark, Andrew J. Yates, Fratricide: A mechanism for T memory-cell homeostasis, Trends Immunol. 24 (2003) 370–375.