Autoimmunity arising from bystander proliferation of T cells in an immune response model
Burroughs, Nigel John, Ferreira, M., Oliveira, B. M. P. M. and Pinto, A. A.. (2011) Autoimmunity arising from bystander proliferation of T cells in an immune response model. Mathematical and Computer Modelling, Vol.53 (No.7-8). pp. 1389-1393. ISSN 0895-7177Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.mcm.2010.01.020
We study a mathematical model of immune response by T cells where the regulatory T cells (Treg) inhibit interleukin 2 secretion. The bystander proliferation to an immune response is modelled. We consider an asymmetry reflecting that the difference between the growth and death rates can be higher for the active T cells and Tregs than for the inactive. This asymmetry leads to a better understanding of the bystander proliferation. An exposure to a pathogen results in an increased proliferation rate of the bystander T cells. If the population of the bystander T cells becomes large enough, autoimmunity can arise, eventually after a long transient period. (C) 2010 Elsevier Ltd. All rights reserved.
|Item Type:||Journal Article|
|Subjects:||Q Science > QA Mathematics|
|Divisions:||Faculty of Science > Mathematics|
|Journal or Publication Title:||Mathematical and Computer Modelling|
|Page Range:||pp. 1389-1393|
|Funder:||FCT , Ministerio da Ciencia, Tecnologia e do Ensino Superior, Calouste Gulbenkian Foundation , Centro de Matematica da Universidade do Minho (CMAT), Centro de Matematica da Universidade do Porto (CMUP) , PRODEP III by FSE , European Union|
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