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Autoimmunity arising from bystander proliferation of T cells in an immune response model

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Burroughs, Nigel John, Ferreira, M. (Miguel), Oliveira, B. M. P. M. and Pinto, Alberto A.. (2011) Autoimmunity arising from bystander proliferation of T cells in an immune response model. Mathematical and Computer Modelling, Volume 53 (Numbers 7-8). pp. 1389-1393. ISSN 0895-7177

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Abstract

We study a mathematical model of immune response by T cells where the regulatory T cells (Treg) inhibit interleukin 2 secretion. The bystander proliferation to an immune response is modelled. We consider an asymmetry reflecting that the difference between the growth and death rates can be higher for the active T cells and Tregs than for the inactive. This asymmetry leads to a better understanding of the bystander proliferation. An exposure to a pathogen results in an increased proliferation rate of the bystander T cells. If the population of the bystander T cells becomes large enough, autoimmunity can arise, eventually after a long transient period. (C) 2010 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Subjects: Q Science > QA Mathematics
Q Science > QR Microbiology > QR180 Immunology
Divisions: Faculty of Science > Mathematics
Library of Congress Subject Headings (LCSH): Immune response -- Mathematical models, T cells, Cytokines
Journal or Publication Title: Mathematical and Computer Modelling
Publisher: Pergamon
ISSN: 0895-7177
Official Date: April 2011
Volume: Volume 53
Number: Numbers 7-8
Page Range: pp. 1389-1393
Identification Number: 10.1016/j.mcm.2010.01.020
Status: Peer Reviewed
Publication Status: Published
Funder: Fundação para a Ciência e a Tecnologia (FCT), Ministerio da Ciencia, Tecnologia e do Ensino Superior, Calouste Gulbenkian Foundation , Universidade do Minho (UdM), Universidade do Porto, European Social Fund (ESF), European Union (EU)
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URI: http://wrap.warwick.ac.uk/id/eprint/39813

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