Immune response dynamics
Burroughs, Nigel John, Oliveira, B. M. P. M., Pinto, A. A. and Ferreira, M.. (2011) Immune response dynamics. Mathematical and Computer Modelling, Volume 53 (Numbers 7-8). pp. 1410-1419. ISSN 0895-7177Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.mcm.2010.02.040
The consequences of regulatory T cell (Treg) inhibition of interleukine 2 secretion are examined by mathematical modelling. We determine the analytic formula that describes the fine balance between Regulatory T cells and T cells at controlled and immune response equilibrium states. We demonstrate that cytokine dependent growth exhibits a quorum T cell population threshold that determines if immune responses develop on activation. We determine the analytic formulas of T cell proliferation thresholds that allow us to study the sensibility of the quorum growth thresholds controlling immune responses. (C) 2010 Elsevier Ltd. All rights reserved.
|Item Type:||Journal Article|
|Subjects:||Q Science > QA Mathematics
Q Science > QR Microbiology > QR180 Immunology
|Divisions:||Faculty of Science > Mathematics|
|Library of Congress Subject Headings (LCSH):||Immune response, Cytokines, Secretion -- Regulation, T cells|
|Journal or Publication Title:||Mathematical and Computer Modelling|
|Page Range:||pp. 1410-1419|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||Fundação para a Ciência e a Tecnologia (FCT), Fundação Calouste Gulbenkian (FCG), Portugal. Ministério da Ciência, Tecnologia e Ensino Superior (MCTES), European Social Fund (ESF), European Union (EU), Universidade do Minho. Centro de Matematica, Universidade do Porto. Centro de Matematica|
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