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Burroughs, Nigel John, Oliveira, B. M. P. M., Pinto, A. A. and Ferreira, M. (2011) Immune response dynamics. Mathematical and Computer Modelling, Volume 53 (Numbers 7-8). pp. 1410-1419. doi:10.1016/j.mcm.2010.02.040 ISSN 0895-7177.
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Official URL: http://dx.doi.org/10.1016/j.mcm.2010.02.040
Abstract
The consequences of regulatory T cell (Treg) inhibition of interleukine 2 secretion are examined by mathematical modelling. We determine the analytic formula that describes the fine balance between Regulatory T cells and T cells at controlled and immune response equilibrium states. We demonstrate that cytokine dependent growth exhibits a quorum T cell population threshold that determines if immune responses develop on activation. We determine the analytic formulas of T cell proliferation thresholds that allow us to study the sensibility of the quorum growth thresholds controlling immune responses. (C) 2010 Elsevier Ltd. All rights reserved.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QA Mathematics Q Science > QR Microbiology > QR180 Immunology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Mathematics | ||||
| Library of Congress Subject Headings (LCSH): | Immune response, Cytokines, Secretion -- Regulation, T cells | ||||
| Journal or Publication Title: | Mathematical and Computer Modelling | ||||
| Publisher: | Pergamon | ||||
| ISSN: | 0895-7177 | ||||
| Official Date: | April 2011 | ||||
| Dates: |
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| Volume: | Volume 53 | ||||
| Number: | Numbers 7-8 | ||||
| Page Range: | pp. 1410-1419 | ||||
| DOI: | 10.1016/j.mcm.2010.02.040 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Fundação para a Ciência e a Tecnologia (FCT), Fundação Calouste Gulbenkian (FCG), Portugal. Ministério da Ciência, Tecnologia e Ensino Superior (MCTES), European Social Fund (ESF), European Union (EU), Universidade do Minho. Centro de Matematica, Universidade do Porto. Centro de Matematica |
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