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Stereocomplexation in novel degradable amphiphilic block copolymer micelles of poly(ethylene oxide) and poly(benzyl α-malate)
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Pounder, Ryan J., Willcock, Helen, Ieong, Nga Sze, O'Reilly, Rachel K. and Dove, Andrew P. (2011) Stereocomplexation in novel degradable amphiphilic block copolymer micelles of poly(ethylene oxide) and poly(benzyl α-malate). Soft Matter, Vol.7 (No.22). pp. 10987-10993. doi:10.1039/c1sm06164j ISSN 1744-683X.
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Official URL: http://dx.doi.org/10.1039/c1sm06164j
Abstract
The ring-opening polymerization of 5-(S)-[(benzyloxycarbonyl) methyl]-1,3-dioxolane-2,4-dione (L-malOCA) and 5-(R)-[(benzyloxycarbonyl) methyl]-1,3-dioxolane-2,4-dione (D-malOCA) from poly (ethylene oxide), PEO, macroinitiators using 4-methoxypyridine as the catalyst is reported. The self-assembly of these polymeric amphiphiles was shown to proceed most efficiently by a solvent switch methodology from THF to nanopure H(2)O. Variation of the block lengths revealed that, as expected, larger block copolymers led to increased micelle dimensions as determined by dynamic light scattering (DLS) and transmission electron microscopy (TEM) and longer hydrophobic blocks led to increased micelle stabilities as determined by measurement of the critical micelle concentration (CMC). Furthermore, the self-assembly of equimolar mixtures of PEO-b-P(L-BMA) and PEO-b-P(D-BMA) resulted in micelles of increased sizes by both DLS and TEM analysis. These micelles also have a CMC value of 5.53 x 10(-3) g L(-1) which is markedly lower than micelles formed from either enantiopure block copolymer (CMC values 1.23 x 10(-2) g L(-1) and 9.78 x 10(-3) g L(-1) for micelles formed from PEO-b-P (L-BMA) and PEO-b-P(D-BMA) respectively).
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Ring-opening polymerization, Drug delivery systems, Malic acid, Block copolymers, Nanoparticles, Paclitaxel, Drug carriers (Pharmacy) | ||||
Journal or Publication Title: | Soft Matter | ||||
Publisher: | Royal Society of Chemistry | ||||
ISSN: | 1744-683X | ||||
Official Date: | 27 September 2011 | ||||
Dates: |
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Volume: | Vol.7 | ||||
Number: | No.22 | ||||
Page Range: | pp. 10987-10993 | ||||
DOI: | 10.1039/c1sm06164j | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | Research Councils UK (RCUK), Engineering and Physical Sciences Research Council (EPSRC), Advantage West Midlands (AWM) , European Regional Development Fund (ERDF) | ||||
Grant number: | EP/G004897/1 (EPSRC) |
Data sourced from Thomson Reuters' Web of Knowledge
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