Möhlig, Matthias, Arafat, A. M., Osterhoff, M. A., Isken, Frank, Weickert, Martin O., Spranger, J., Pfeiffer, Andreas F. H. and Schofl, C.. (2011) Androgen receptor CAG repeat length polymorphism modifies the impact of testosterone on insulin sensitivity in men. European Journal of Endocrinology, Vol.164 (No.6). pp. 1013-1018. ISSN 0804-4643

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Abstract

Objective: Low circulating testosterone concentrations have been associated with insulin resistance (IR). Androgen action is mediated by the androgen receptor (AR) whose activity is modulated by a polymorphic CAG repeat sequence within exon 1. An interaction between testosterone and CAG repeat length (CAG length) with respect to IR has been described in women. Objective: We investigated such a putative interaction between testosterone and the CAG length with respect to IR in men with normal glucose tolerance. Design: Cross-sectional study. Methods: In 113 non-diabetic men calculated free testosterone, the CAG length, and a multiplicative interaction term were investigated by multiple linear regression analysis for an association with IR, as indicated by homeostasis model assessment (HOMA %S). Results: In a multivariate regression analysis adjusted for age and body mass index, free testosterone, CAG length, and a multiplicative interaction term were significantly associated with IR (P=0.001, P=0.001, P=0.01 respectively). The model explained 36.6% of the variation of IR and predicted that in carriers with a CAG length of 23, changes in testosterone would only minimally affect IR. For CAG lengths longer than 23, however, an increase in testosterone would improve IR, namely the longer the CAG length, the greater the effect. In contrast, in the case of CAG lengths shorter than 23, the effect of increasing testosterone would be the opposite. Conclusions: In men, testosterone and the AR CAG repeat length polymorphism interacted with respect to IR. The interpretation of the association between testosterone and IR seems to require consideration of the AR CAG repeat polymorphism.

Item Type:	Journal Article
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine
Divisions:	Faculty of Medicine > Warwick Medical School > Clinical Sciences Research Institute (CSRI) Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Globulins, Polycystic ovary syndrome, Metabolic syndrome, Testosterone, Prostate -- Cancer, Hypogonadism, Androgen-binding proteins
Journal or Publication Title:	European Journal of Endocrinology
Publisher:	BioScientifica Ltd.
ISSN:	0804-4643
Date:	June 2011
Volume:	Vol.164
Number:	No.6
Page Range:	pp. 1013-1018
Identification Number:	10.1530/EJE-10-1022
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Bayer Vital GmbH
URI:	http://wrap.warwick.ac.uk/id/eprint/39961

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