Kihm, L. P., Muller-Krebs, S., Klein, Julia, Ehrlich, G. (Gregory), Mertes, L., Gross, Marie-Luise, Adaikalakoteswari, A., Thornalley, Paul J., Hammes, H.-P., Nawroth, P. P. (Peter P.), 1954-, Zeier, M. (Martin) and Schwenger, Vedat. (2011) Benfotiamine protects against peritoneal and kidney damage in peritoneal dialysis. Journal of the American Society of Nephrology, Vol.22 (No.5). pp. 914-926. ISSN 1046-6673

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Abstract

Residual renal function and the integrity of the peritoneal membrane contribute to morbidity and mortality among patients treated with peritoneal dialysis. Glucose and its degradation products likely contribute to the deterioration of the remnant kidney and damage to the peritoneum. Benfotiamine decreases glucose-induced tissue damage, suggesting the potential for benefit in peritoneal dialysis. Here, in a model of peritoneal dialysis in uremic rats, treatment with benfotiamine decreased peritoneal fibrosis, markers of inflammation, and neovascularization, resulting in improved characteristics of peritoneal transport. Furthermore, rats treated with benfotiamine exhibited lower expression of advanced glycation endproducts and their receptor in the peritoneum and the kidney, reduced glomerular and tubulointerstitial damage, and less albuminuria. Increased activity of transketolase in tissue and blood contributed to the protective effects of benfotiamine. In primary human peritoneal mesothelial cells, the addition of benfotiamine led to enhanced transketolase activity and decreased expression of advanced glycation endproducts and their receptor. Taken together, these data suggest that benfotiamine protects the peritoneal membrane and remnant kidney in a rat model of peritoneal dialysis and uremia.

Item Type:	Journal Article
Subjects:	R Medicine > RB Pathology R Medicine > RC Internal medicine
Divisions:	Faculty of Medicine > Warwick Medical School > Translational & Systems Medicine > Metabolic and Vascular Health Faculty of Medicine > Warwick Medical School Faculty of Medicine > Warwick Medical School > Translational & Systems Medicine
Library of Congress Subject Headings (LCSH):	Peritoneal dialysis, Vascular endothelium, Oxidative stress, Hyperglycemia, Vitamin B1
Journal or Publication Title:	Journal of the American Society of Nephrology
Publisher:	American Society of Nephrology
ISSN:	1046-6673
Official Date:	May 2011
Volume:	Vol.22
Number:	No.5
Page Range:	pp. 914-926
Identification Number:	10.1681/ASN.2010070750
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Gambro (Firm), Worwag Pharma
URI:	http://wrap.warwick.ac.uk/id/eprint/40021

Data sourced from Thomson Reuters' Web of Knowledge

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