Wu, Ye-Lin, Huang, Jing, Liu, Jian, Jin, Ming-Fei, Gu, Mei, Hong, Yiguo and Wu, Zi-Rong (2011) Protective effect of recombinant human glucagon-like peptide-1 (rhGLP-1) pretreatment in STZ-induced diabetic mice. Journal of Peptide Science, Vol.17 (No.7). pp. 499-504. doi:10.1002/psc.1352

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Abstract

Human glucagon-like peptide-1 (hGLP-1) and its mimetics have emerged as therapies for type 2 diabetes. However, clinical treatment of diabetes with hGLP-1 is ineffective because of rapid DPPIV-mediated hGLP-1 degradation in the circulation. In this study, we investigated the protective effect of recombinant human glucagon-like peptide-1 (rhGLP-1) treatment on STZ-induced diabeticmice. Mice were treated daily with rhGLP-1 (24 nmol/kg body weight) starting before or after STZ injection (40mg/kg body weight) to induce diabetes. Mice pretreated with rhGLP-1 before but not after STZ showed significantly reduced blood glucose levels (P < 0.05), increased oral glucose tolerance (area under the curve, 1740 +/- 71.18 vs 2416 +/- 205.6, P < 0.05). Furthermore, the bioproduct of lipid peroxidation, MDA, was reduced and SOD and GSH-PX activities were enhanced globally and in pancreas of mice that received rhGLP-1 pretreatment before STZ, when comparing with STZ-treated mice. Finally, STZ-induced pancreatic islet damage was rescued by rhGLP-1 pretreatment. Taken together, the results of this study demonstrate that rhGLP-1 pretreatment has a protective effect against STZ-induced diabetes in mice. These findings suggest that the GLP-1 pretreatment may be a new therapeutic strategy in the preventive and protective treatment during diabetes initiation and progression. Copyright (C) 2011 European Peptide Society and John Wiley & Sons, Ltd.

Item Type:	Journal Article
Subjects:	R Medicine > RB Pathology R Medicine > RC Internal medicine
Divisions:	Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Warwick HRI (2004-2010) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Streptozotocin, Oxidative stress, Diabetes, Non-insulin-dependent diabetes, Glucagon-like peptide 1
Journal or Publication Title:	Journal of Peptide Science
Publisher:	John Wiley & Sons Ltd.
ISSN:	10752617
Official Date:	July 2011
Dates:	Date Event July 2011 Published
Volume:	Vol.17
Number:	No.7
Page Range:	pp. 499-504
DOI:	10.1002/psc.1352
Status:	Peer Reviewed
Publication Status:	Published
Funder:	National New Drug Development Program of China
Grant number:	2009ZX09102-253 (NNDDPC)

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