Ainslie PN, Burgess K, Subedi P, Burgess KR (2007)
Alterations in cerebral dynamics at high altitude
following partial acclimatization in humans: wakefulness
and sleep. J Appl Physiol 102:658–64
Ainslie PN, Ogoh S, Burgess K, Celi L, McGrattan K,
Peebles K, Murrell C, Subedi P, Burgess KR (2008)
Differential effects of acute hypoxia and high altitude on
cerebral blood flow velocity and dynamic cerebral
autoregulation: alterations with hyperoxia. J Appl
Physiol 104:490–8
Appenzeller O, Passino C, Roach R, Gamboa J, Gamboa A,
Bernardi L, Bonfichi M, Malcovati L (2004) Cerebral
vasoreactivity in Andeans and headache at sea level.
J Neurol Sci 219:101–6
Baumgartner RW, Bartsch P, Maggiorini M, Waber U, Oelz
O (1994) Enhanced cerebral blood flow in acute
mountain sickness. Aviat Space Environ Med 65:726–9
Baumgartner RW, Spyridopoulos I, Bartsch P, Maggiorini
M, Oelz O (1999) Acute mountain sickness is not related
to cerebral blood flow: a decompression chamber study.
J Appl Physiol 86:1578–82
Beckmann N (2000) High resolution magnetic resonance
angiography non-invasively reveals mouse strain differences
in the cerebrovascular anatomy in vivo. Magn
Reson Med 44:252–8
Besselmann M, Liu M, Diedenhofen M, Franke C, Hoehn M
(2001) MR angiographic investigation of transient focal
cerebral ischemia in rat. NMR Biomed 14:289–96
Brugniaux JV, Hodges AN, Hanly PJ, Poulin MJ (2007)
Cerebrovascular responses to altitude. Respir Physiol
Neurobiol 158:212–23
Chan CW, Hoar H, Pattinson K, Bradwell AR, Wright AD,
Imray CH (2005) Effect of sildenafil and acclimatization
on cerebral oxygenation at altitude. Clin Sci (Lond)
109:319–24
Choy M, Ganesan V, Thomas DL, Thornton JS, Proctor E,
King MD, van derWeerd L, Gadian DG, LythgoeMF (2006)
The chronic vascular and haemodynamic response after
permanent bilateral common carotid occlusion in newborn
and adult rats. J Cereb Blood Flow Metab 26:
1066–75
Du Boulay GH, Symon L (1971) The anaesthetist’s effect
upon the cerebral arteries. Proc R Soc Med 64:77–80
Feddersen B, Ausserer H, Neupane P, Thanbichler F,
Depaulis A, Waanders R, Noachtar S (2007) Right
temporal cerebral dysfunction heralds symptoms of
acute mountain sickness. J Neurol 254:359–63
Firth PG, Zheng H, Windsor JS, Sutherland AI, Imray CH,
Moore GW, Semple JL, Roach RC, Salisbury RA (2008)
Mortality on Mount Everest, 1921 to 2006: descriptive
study. BMJ 337:a2654
Giller CA (2003) The Emperor has no clothes: velocity,
flow, and the use of TCD. J Neuroimaging 13:97–8
Giller CA, Bowman G, Dyer H, Mootz L, Krippner W (1993)
Cerebral arterial diameters during changes in blood
pressure and carbon dioxide during craniotomy.
Neurosurgery 32:737–41; discussion 41–42
Giller CA, Giller AM, Cooper CR, Hatab MR (2000)
Evaluation of the cerebral hemodynamic response to
rhythmic handgrip. J Appl Physiol 88:2205–13
Gonzalez NR, Boscardin WJ, Glenn T, Vinuela F, Martin NA
(2007) Vasospasm probability index: a combination of
transcranial Doppler velocities, cerebral blood flow, and
clinical risk factors to predict cerebral vasospasm after
aneurysmal subarachnoid hemorrhage. J Neurosurg
107:1101–12
Grocott MP, Martin DS, Levett DZ, McMorrow R,
Windsor J, Montgomery HE (2009) Arterial blood gases
and oxygen content in climbers on Mount Everest.
N Engl J Med 360:140–9
Grocott MP, Martin DS, Wilson MH, Mitchell K, Dhillon S,
Mythen MG, Montgomery HE, Levett DZ (2010) Caudwell
xtreme Everest expedition. High Alt Med Biol 11:133–7
Hansen JM, Pedersen D, Larsen VA, et al (2007) Magnetic
resonance angiography shows dilatation of the middle
cerebral artery after infusion of glyceryl trinitrate in
healthy volunteers . Cephalalgia 27:118–27
Imray CH, Myers SD, Pattinson KT, Bradwell AR, Chan
CW, Harris S, Collins P, Wright AD (2005) Effect of
exercise on cerebral perfusion in humans at high
altitude. J Appl Physiol 99:699–706
Jansen GF, Kagenaar DA, Basnyat B, Odoom JA (2002)
Basilar artery blood flow velocity and the ventilatory
response to acute hypoxia in mountaineers. Respir
Physiol Neurobiol 133:65–74
Jansen GF, Krins A, Basnyat B, Bosch A, Odoom JA (2000)
Cerebral autoregulation in subjects adapted and not
adapted to high altitude. Stroke 31:2314–8
Lysakowski C, Von Elm E, Dumont L, Junod JD, Tassonyi E,
Kayser B, Tramer MR (2004) Effect of magnesium, high
altitude and acute mountain sickness on blood flow
velocity in the middle cerebral artery. Clin Sci (Lond)
106:279–85
Martinoli C, Derchi LE (1997) Gain setting in power
Doppler US. Radiology 202:284–5
Moller K, Paulson OB, Hornbein TF, Colier WN, Paulson
AS, Roach RC, Holm S, Knudsen GM (2002) Unchanged
cerebral blood flow and oxidative metabolism after
acclimatization to high altitude. J Cereb Blood Flow
Metab 22:118–26
Muller M, Schwerdtfeger K, Zieroth S (2000) Assessment of
middle cerebral artery diameter after aneurysmal
subarachnoid hemorrhage by transcranial color-coded
duplex sonography. Eur J Ultrasound 11:15–9
Norcliffe LJ, Rivera-Ch M, Claydon VE, Moore JP,
Leon-Velarde F, Appenzeller O, Hainsworth R
(2005) Cerebrovascular responses to hypoxia and
hypocapnia in high-altitude dwellers. J Physiol 566:
287–94
Nuttall GA, Cook DJ, Fulgham JR, Oliver Jr WC, Proper JA
(1996) The relationship between cerebral blood flow
and transcranial Doppler blood flow velocity during
hypothermic cardiopulmonary bypass in adults. Anesth
Analg 82:1146–51
Otis SM, Rossman ME, Schneider PA, Rush MP, Ringelstein
EB (1989) Relationship of cerebral blood flow
regulation to acute mountain sickness. J Ultrasound
Med 8:143–8
Pai SB, Varma RG, Kulkarni RN (2005)Microsurgical anatomy
of the middle cerebral artery. Neurol India 53:186–90
Palma J, Macedonia C, Deuster P, Olsen C, Mozayeni BR,
Crutchfield KE (2006) Cerebrovascular dynamics and
vascular endothelial growth factor in acute mountain
sickness. Wilderness Environ Med 17:1–7
Poulin MJ, Robbins PA (1996) Indexes of flow and crosssectional
area of the middle cerebral artery using
Doppler ultrasound during hypoxia and hypercapnia
in humans. Stroke 27:2244–50
Reese T, Bochelen D, Sauter A, Beckmann N, Rudin M
(1999) Magnetic resonance angiography of the rat
cerebrovascular system without the use of contrast
agents. NMR Biomed 12:189–96
Schreiber SJ, Gottschalk S, Weih M, Villringer A, Valdueza
JM (2000) Assessment of blood flow velocity and
diameter of the middle cerebral artery during the
acetazolamide provocation test by use of transcranial
Doppler sonography and MR imaging. AJNR Am J
Neuroradiol 21:1207–1
Serrador JM, Picot PA, Rutt BK, Shoemaker JK, Bondar RL
(2000) MRI measures of middle cerebral artery
diameter in conscious humans during simulated orthostasis.
Stroke 31:1672–8
Subudhi AW, Dimmen AC, Roach RC (2007) Effects of
acute hypoxia on cerebral and muscle oxygenation
during incremental exercise. J Appl Physiol 103:177–83
Tarasow E, Abdulwahed Saleh Ali A, Lewszuk A,Walecki J
(2007) Measurements of the middle cerebral artery in
digital subtraction angiography and MR angiography.
Med Sci Monit 13 (Suppl 1):65–72
Ter Minassian A, Beydon L, Ursino M, Gardette B, Gortan
C, Richalet JP (2001) Doppler study of middle cerebral
artery blood flow velocity and cerebral autoregulation
during a simulated ascent of Mount Everest. Wilderness
Environ Med 12:175–83
The National Institute of Neurological Disorders and
Stroke rt-PA Stroke Study Group (1995) Tissue plasminogen
activator for acute ischemic stroke. N Engl J Med
333:1581–7
Valdueza JM, Balzer JO, Villringer A, Vogl TJ, Kutter R,
Einhaupl KM (1997) Changes in blood flow velocity and
diameter of the middle cerebral artery during hyperventilation:
assessment with MR and transcranial
Doppler sonography. AJNR Am J Neuroradiol 18:
1929–34
Van Osta A, Moraine JJ, Melot C, Mairbaurl H, Maggiorini
M, Naeije R (2005) Effects of high altitude exposure on
cerebral hemodynamics in normal subjects. Stroke
36:557–60
Virues-Ortega J, Buela-Casal G, Garrido E, Alcazar B (2004)
Neuropsychological functioning associated with highaltitude
exposure. Neuropsychol Rev 14:197–224
Ward M, Milledge JS, West JB (2000) High Altitude
Physiology. 3rd edn. London: Arnold Publishers
Weyland A, Stephan H, Kazmaier S, Weyland W, Schorn B,
Grune F, Sonntag H (1994) Flow velocity measurements
as an index of cerebral blood flow. Validity of transcranial
Doppler sonographic monitoring during cardiac
surgery. Anesthesiology 81:1401–10
Wilson MH, Levett DZ, Dhillon S, Mitchell K, Morgan J,
Grocott MP, Imray C (2011) Stroke at high altitude
diagnosed in the field using portable ultrasound. Wilderness
Environ Med 22:54–7
Wilson MH, Newman S, Imray CH (2009) The cerebral
effects of ascent to high altitudes. Lancet Neurol 8:175–91
Wolff CB, Richardson N, Kemp O, Kuttler A, McMorrow R,
Hart N, Imray CH (2007) Near infra-red spectroscopy
and arterial oxygen extraction at altitude. Adv Exp Med
Biol 599:183–9
Wollman H, Smith TC, Stephen GW, Colton III ET, Gleaton
HE, Alexander SC (1968) Effects of extremes of
respiratory and metabolic alkalosis on cerebral blood
flow in man. J Appl Physiol 24:60–5
Zuj KA, Greaves DK, Hughson RL (2007) WISE-2005:
reduced cerebral blood flow velocity with nitroglycerin–
comparison with common carotid artery blood flow.
J Gravit Physiol 14:P65–6