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A new target for modulating human artery function : calcium-independent phospholipase A2B modulates receptor-mediated contraction
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Watkins, J., Marsh, A. (Andrew), Shmygol, Anatoly, James, Sean, Dimitri, W. and Singer, Donald R. J. (2011) A new target for modulating human artery function : calcium-independent phospholipase A2B modulates receptor-mediated contraction. In: 10th Congress of the European Association for Clinical Pharmacology and Therapeutics, Budapest, Hungary, 26-29 June 2011. Published in: Basic & Clinical Pharmacology & Toxicology, Vol.109 (No.S1). p. 32.
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Official URL: http://dx.doi.org/10.1111/(ISSN)1742-7843
Abstract
Animal studies suggest a role for calcium-independent phospholipase A2 (iPLA2b) in G-protein coupled receptor-mediated but not ion channel-induced constriction in cerebral arteries and the abdominal aorta. Purpose: We assessed whether iPLA2b may be implicated in regulating tone in human vascular conduits, using S-bromoenolactone (S-BEL), a stereo-selective suicide substrate inhibitor of iPLA2b, with its stereo-isomer R-BEL as control.
| Item Type: | Conference Item (Paper) |
|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QP Physiology R Medicine > RC Internal medicine |
| Divisions: | Faculty of Science > Chemistry Faculty of Medicine > Warwick Medical School > Clinical Sciences Research Institute (CSRI) Faculty of Medicine > Warwick Medical School |
| Library of Congress Subject Headings (LCSH): | Arteries -- Physiology, Phospholipase A2 |
| Journal or Publication Title: | Basic & Clinical Pharmacology & Toxicology |
| Publisher: | Wiley-Blackwell Publishing Ltd. |
| ISSN: | 1742-7851 |
| Date: | June 2011 |
| Volume: | Vol.109 |
| Number: | No.S1 |
| Page Range: | p. 32 |
| Identification Number: | 10.1111/(ISSN)1742-7843 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Description: | Special Issue: Abstracts of the 10th Congress of the European Association for Clinical Pharmacology and Therapeutics, 26-29 June 2011, Budapest, Hungary |
| Conference Paper Type: | Paper |
| Title of Event: | 10th Congress of the European Association for Clinical Pharmacology and Therapeutics |
| Type of Event: | Conference |
| Location of Event: | Budapest, Hungary |
| Date(s) of Event: | 26-29 June 2011 |
| URI: | http://wrap.warwick.ac.uk/id/eprint/40209 |
Data sourced from Thomson Reuters' Web of Knowledge
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