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A new target for modulating human artery function : calcium-independent phospholipase A2B modulates receptor-mediated contraction
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Watkins, J., Marsh, Andrew, Shmygol, Anatoly, James, Sean G., Dimitri, W. and Singer, Donald R. J. (2011) A new target for modulating human artery function : calcium-independent phospholipase A2B modulates receptor-mediated contraction. In: 10th Congress of the European Association for Clinical Pharmacology and Therapeutics, Budapest, Hungary, 26-29 June 2011. Published in: Basic & Clinical Pharmacology & Toxicology, Vol.109 (No.S1). p. 32. doi:10.1111/(ISSN)1742-7843 ISSN 1742-7851 .
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Official URL: http://dx.doi.org/10.1111/(ISSN)1742-7843
Abstract
Animal studies suggest a role for calcium-independent
phospholipase A2 (iPLA2b) in G-protein coupled receptor-mediated but
not ion channel-induced constriction in cerebral arteries and the abdominal
aorta. Purpose: We assessed whether iPLA2b may be implicated in
regulating tone in human vascular conduits, using S-bromoenolactone
(S-BEL), a stereo-selective suicide substrate inhibitor of iPLA2b, with its
stereo-isomer R-BEL as control.
| Item Type: | Conference Item (Paper) | ||||
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| Subjects: | Q Science > QD Chemistry Q Science > QP Physiology R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Arteries -- Physiology, Phospholipase A2 | ||||
| Journal or Publication Title: | Basic & Clinical Pharmacology & Toxicology | ||||
| Publisher: | Wiley-Blackwell Publishing Ltd. | ||||
| ISSN: | 1742-7851 | ||||
| Official Date: | June 2011 | ||||
| Dates: |
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| Volume: | Vol.109 | ||||
| Number: | No.S1 | ||||
| Page Range: | p. 32 | ||||
| DOI: | 10.1111/(ISSN)1742-7843 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Description: | Special Issue: Abstracts of the 10th Congress of the European Association for Clinical Pharmacology and Therapeutics, 26-29 June 2011, Budapest, Hungary |
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| Conference Paper Type: | Paper | ||||
| Title of Event: | 10th Congress of the European Association for Clinical Pharmacology and Therapeutics | ||||
| Type of Event: | Conference | ||||
| Location of Event: | Budapest, Hungary | ||||
| Date(s) of Event: | 26-29 June 2011 |
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