Arabidopsis Interactome Mapping Consortium (Including:

). (2011) Evidence for network evolution in an Arabidopsis interactome map. Science, Vol.333 (No.6042). pp. 601-607. ISSN 0036-8075

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Abstract

Plants have unique features that evolved in response to their environments and ecosystems. A full account of the complex cellular networks that underlie plant-specific functions is still missing. We describe a proteome-wide binary protein-protein interaction map for the interactome network of the plant Arabidopsis thaliana containing about 6200 highly reliable interactions between about 2700 proteins. A global organization of plant biological processes emerges from community analyses of the resulting network, together with large numbers of novel hypothetical functional links between proteins and pathways. We observe a dynamic rewiring of interactions following gene duplication events, providing evidence for a model of evolution acting upon interactome networks. This and future plant interactome maps should facilitate systems approaches to better understand plant biology and improve crops.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH426 Genetics Q Science > QK Botany
Divisions:	Faculty of Science > Centre for Systems Biology
Library of Congress Subject Headings (LCSH):	Arabidopsis thaliana, Arabidopsis thaliana -- Genome mapping, Protein-protein interactions, Biological systems, Information theory in biology
Journal or Publication Title:	Science
Publisher:	American Association for the Advancement of Science
ISSN:	0036-8075
Official Date:	29 July 2011
Dates:	Date Event 29 July 2011 Published
Volume:	Vol.333
Number:	No.6042
Page Range:	pp. 601-607
Identification Number:	10.1126/science.1203877
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	National Science Foundation (U.S.) (NSF), National Human Genome Research Institute (U.S.) (NHGRI), Canada Excellence Research Chairs (CERC), Canadian Institute for Advanced Research (CIAR), James S. McDonnell Foundation (JSMF), Sixth Framework Programme (European Commission) (FP6), National Institute of General Medical Sciences (U.S.) (NIGMS), United States. Agricultural Research Service (ARS), National Institutes of Health (U.S.) (NIH), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC)
Grant number:	0703905 (NSF), R01HG001715 (NHGRI), 0520253 (NSF), 0313578 (NSF), 220020084 (JSMF), LSHG-CT-2006-037704 (FP6), R01GM066025 (NIGMS), 1907-21000-030 (ARS), F32HG004098 (NIH), F32HG004830 (NIH), F005806 (BBSRC), 0703908 (NSF)
URI:	http://wrap.warwick.ac.uk/id/eprint/40216

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