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Independently evolved virulence effectors converge onto hubs in a plant immune system network
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European Union Effectoromics Consortium (Including:
). (2011) Independently evolved virulence effectors converge onto hubs in a plant immune system network. Science, Vol.333 (No.6042). pp. 596-601. doi:10.1126/science.1203659 Research output not available from this repository, contact author.
Official URL: http://dx.doi.org/10.1126/science.1203659
Abstract
Plants generate effective responses to infection by recognizing both conserved and variable pathogen-encoded molecules. Pathogens deploy virulence effector proteins into host cells, where they interact physically with host proteins to modulate defense. We generated an interaction network of plant-pathogen effectors from two pathogens spanning the eukaryote-eubacteria divergence, three classes of Arabidopsis immune system proteins, and ~8000 other Arabidopsis proteins. We noted convergence of effectors onto highly interconnected host proteins and indirect, rather than direct, connections between effectors and plant immune receptors. We demonstrated plant immune system functions for 15 of 17 tested host proteins that interact with effectors from both pathogens. Thus, pathogens from different kingdoms deploy independently evolved virulence proteins that interact with a limited set of highly connected cellular hubs to facilitate their diverse life-cycle strategies.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QH Natural history > QH426 Genetics Q Science > QK Botany Q Science > QR Microbiology > QR180 Immunology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre |
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| Library of Congress Subject Headings (LCSH): | Arabidopsis thaliana, Natural immunity, Arabidopsis thaliana -- Genome mapping, Arabidopsis thaliana -- Disease and pest resistance | ||||
| Journal or Publication Title: | Science | ||||
| Publisher: | American Association for the Advancement of Science | ||||
| ISSN: | 0036-8075 | ||||
| Official Date: | 29 July 2011 | ||||
| Dates: |
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| Volume: | Vol.333 | ||||
| Number: | No.6042 | ||||
| Page Range: | pp. 596-601 | ||||
| DOI: | 10.1126/science.1203659 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | National Institutes of Health (U.S.) (NIH), National Science Foundation (U.S.) (NSF), United States. Dept. of Energy (DOE), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Sixth Framework Programme (European Commission) (FP6) | ||||
| Grant number: | GM-066025 (NIH), P50-HG004233 (NIH), 2010 0929410 (NSF), 0703905 (NSF), 0520253 (NSF), 0313578 (NSF), 0726408 (NSF), FG02-95ER20187 (DoE), E024815 (BBSRC), F005806 (BBSRC), G015066 (BBSRC), LSHG-CT-2006-037704 (FP6) |
Data sourced from Thomson Reuters' Web of Knowledge
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