(2011) Independently evolved virulence effectors converge onto hubs in a plant immune system network. Science, Vol.333 (No.6042). pp. 596-601. ISSN 0036-8075

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Abstract

Plants generate effective responses to infection by recognizing both conserved and variable pathogen-encoded molecules. Pathogens deploy virulence effector proteins into host cells, where they interact physically with host proteins to modulate defense. We generated an interaction network of plant-pathogen effectors from two pathogens spanning the eukaryote-eubacteria divergence, three classes of Arabidopsis immune system proteins, and ~8000 other Arabidopsis proteins. We noted convergence of effectors onto highly interconnected host proteins and indirect, rather than direct, connections between effectors and plant immune receptors. We demonstrated plant immune system functions for 15 of 17 tested host proteins that interact with effectors from both pathogens. Thus, pathogens from different kingdoms deploy independently evolved virulence proteins that interact with a limited set of highly connected cellular hubs to facilitate their diverse life-cycle strategies.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH426 Genetics Q Science > QK Botany Q Science > QR Microbiology > QR180 Immunology
Divisions:	Faculty of Science > Life Sciences (2010- ) Faculty of Science > Centre for Systems Biology
Library of Congress Subject Headings (LCSH):	Arabidopsis thaliana, Natural immunity, Arabidopsis thaliana -- Genome mapping, Arabidopsis thaliana -- Disease and pest resistance
Journal or Publication Title:	Science
Publisher:	American Association for the Advancement of Science
ISSN:	0036-8075
Official Date:	29 July 2011
Volume:	Vol.333
Number:	No.6042
Page Range:	pp. 596-601
Identification Number:	10.1126/science.1203659
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	National Institutes of Health (U.S.) (NIH), National Science Foundation (U.S.) (NSF), United States. Dept. of Energy (DOE), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Sixth Framework Programme (European Commission) (FP6)
Grant number:	GM-066025 (NIH), P50-HG004233 (NIH), 2010 0929410 (NSF), 0703905 (NSF), 0520253 (NSF), 0313578 (NSF), 0726408 (NSF), FG02-95ER20187 (DoE), E024815 (BBSRC), F005806 (BBSRC), G015066 (BBSRC), LSHG-CT-2006-037704 (FP6)
URI:	http://wrap.warwick.ac.uk/id/eprint/40217

Data sourced from Thomson Reuters' Web of Knowledge

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