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Functionalized, biocompatible coating for superparamagnetic nanoparticles by controlled polymerization of a thioglycosidic monomer

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Babiuch, Krzysztof, Wyrwa, Ralf, Wagner, Kerstin, Seemann, Thomas, Hoeppener, Stephanie, Becer, C. Remzi, Linke, Ralf, Gottschaldt, Michael, Weisser, Jürgen, Schnabelrauch, Matthias and Schubert, Ulrich S. (2011) Functionalized, biocompatible coating for superparamagnetic nanoparticles by controlled polymerization of a thioglycosidic monomer. Biomacromolecules, Vol.12 (No.3). pp. 681-691. doi:10.1021/bm101325w

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Official URL: http://dx.doi.org/10.1021/bm101325w

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Abstract

It is demonstrated that water-soluble, glucosylated poly(pentafluorostyrene) derivatives revealed favorable coating material properties for magnetic iron oxide nanoparticles. To prepare the coating material in high reproducibility and purity as well as in sufficient amounts, a new route of synthesis is established. The preparation and characterization of the glucosylated, tetrafluorostyryl monomer, by thiol-para-fluorine “click” reaction, and its polymerization, via nitroxide-mediated radical process, is presented in detail. In addition, the coating material and the resulting particle properties are investigated by means of XPS, DLS, TGA, TEM, and cryo-TEM as well as flow cytometry. The glycopolymer acts as an appropriate stabilizing agent for the superparamagnetic nanoparticles by the formation of an approximately 10 nm thick shell, as shown by the XPS analysis. Furthermore, the application of FITC-labeled glycopolymer yielded fluorescent, superparamagnetic nanoparticles, which can be used for monitoring cell−carbohydrate interactions, because these particles show no cytotoxicity toward 3T3 fibroblasts.

Item Type: Journal Article
Subjects: Q Science > QC Physics
Q Science > QD Chemistry
Divisions: Faculty of Science > Physics
Library of Congress Subject Headings (LCSH): Polymerization, Radicals (Chemistry), Nanoparticles -- Magnetic properties, Quantum dots, Hydrolysis, Monomers
Journal or Publication Title: Biomacromolecules
Publisher: American Chemical Society
ISSN: 1525-7797
Official Date: March 2011
Dates:
DateEvent
March 2011Published
Volume: Vol.12
Number: No.3
Page Range: pp. 681-691
DOI: 10.1021/bm101325w
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Dutch Polymer Institute (DPI), Germany. Bundesministerium für Wirtschaft und Technologie [Germany. Federal Ministry of Economics and Technology] (BMWi)
Grant number: VF080018 (BMWi)

Data sourced from Thomson Reuters' Web of Knowledge

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