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A potent trans-diimine platinum anticancer complex photoactivated by visible light
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Farrer, Nicola J., Woods, Julie A., Salassa, Luca, Zhao, Yao, (Researcher in chemistry), Robinson, Kim S., Clarkson, Guy J., Mackay, Fiona S. and Sadler, P. J. (2010) A potent trans-diimine platinum anticancer complex photoactivated by visible light. Angewandte Chemie International Edition, Vol.49 (No.47). pp. 8905-8908. doi:10.1002/anie.201003399 ISSN 1433-7851.
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Official URL: http://dx.doi.org/10.1002/anie.201003399
Abstract
Activating platinum with light: An inert platinum(IV) diazido complex trans, trans,trans-[Pt(N3)2(OH)2(py)2] becomes potently cytotoxic to cancer cells when activated by low doses of visible light.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QP Physiology R Medicine > RS Pharmacy and materia medica |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
| Library of Congress Subject Headings (LCSH): | Bioinorganic chemistry, Photochemistry, Antineoplastic agents, Nuclear magnetic resonance spectroscopy, Platinum | ||||
| Journal or Publication Title: | Angewandte Chemie International Edition | ||||
| Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA | ||||
| ISSN: | 1433-7851 | ||||
| Official Date: | 15 November 2010 | ||||
| Dates: |
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| Volume: | Vol.49 | ||||
| Number: | No.47 | ||||
| Page Range: | pp. 8905-8908 | ||||
| DOI: | 10.1002/anie.201003399 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Engineering and Physical Sciences Research Council (EPSRC) , Medical Research Council (Great Britain) (MRC) , European Commission (EC) | ||||
| Grant number: | EP/G006792/1 (EPSRC), G070162 (MRC), 220281 (EC) |
Data sourced from Thomson Reuters' Web of Knowledge
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