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Bacterial cell wall assembly : still an attractive antibacterial target

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Bugg, Tim, Braddick, Darren, Dowson, Christopher G. and Roper, David I. (2011) Bacterial cell wall assembly : still an attractive antibacterial target. Trends in Biotechnology, Vol.29 (No.4). pp. 167-173. doi:10.1016/j.tibtech.2010.12.006

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Official URL: http://dx.doi.org/10.1016/j.tibtech.2010.12.006

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Abstract

The development of new antibacterial agents to combat worsening antibiotic resistance is still a priority area in anti-infectives research, but in the post-genomic era it has been more difficult than expected to identify new lead compounds from high-throughput screening, and very challenging to obtain antibacterial activity for lead compounds. Bacterial cell-wall peptidoglycan biosynthesis is a well-established target for antibacterial chemotherapy, and recent developments enable the entire biosynthetic pathway to be reconstituted for detailed biochemical study and high-throughput inhibitor screening. This review article discusses recent developments in the availability of peptidoglycan biosynthetic intermediates, the identification of lead compounds for both the earlier cytoplasmic steps and the later lipid-linked steps, and the application of new methods such as structure-based drug design, phage display and surface science.

Item Type: Journal Article
Subjects: Q Science > QR Microbiology
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Science > Chemistry
Faculty of Science > Life Sciences (2010- )
Faculty of Science > Centre for Systems Biology
Library of Congress Subject Headings (LCSH): Antibacterial agents, Escherichia coli, Bacterial cell walls -- Synthesis, Peptidoglycans -- Synthesis, Transfer RNA, Streptococcus pneumoniae
Journal or Publication Title: Trends in Biotechnology
Publisher: Elsevier Science BV
ISSN: 0167-7799
Official Date: 2011
Dates:
DateEvent
2011Published
Volume: Vol.29
Number: No.4
Number of Pages: 7
Page Range: pp. 167-173
DOI: 10.1016/j.tibtech.2010.12.006
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

Data sourced from Thomson Reuters' Web of Knowledge

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