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Photoreaction pathways for the anticancer complex trans,trans,trans-[Pt(N3)2(OH)2(NH3)2]
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Ronconi, Luca and Sadler, P. J. (2011) Photoreaction pathways for the anticancer complex trans,trans,trans-[Pt(N3)2(OH)2(NH3)2]. Dalton Transactions, Vol.40 (No.1). pp. 262-268. doi:10.1039/c0dt00546k ISSN 1477-9226.
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Official URL: http://dx.doi.org/10.1039/C0DT00546K
Abstract
The photodecomposition of the anticancer complex trans,trans,trans-[Pt(N3)2(OH)2(NH3)2] in acidic aqueous solution, as well as in phosphate-buffered saline (PBS), induced by UVA light (centred at λ = 365 nm) has been studied by multinuclear NMR spectroscopy. We show that the photoreaction pathway in PBS, which involves azide release, differs from that in acidic aqueous conditions, under which N2 is a major product. In both cases, a number of trans-{N–Pt(II/IV)–NH3} species were also observed as photoproducts, as well as the evolution of O2 and release of free ammonia with a subsequent increase in pH. The results from this study illustrate that photoinduced reactions of Pt(IV)-diazido derivatives can lead to novel reaction pathways, and therefore potentially to new cytotoxic mechanisms in cancer cells.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry Q Science > QP Physiology R Medicine > RM Therapeutics. Pharmacology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Photochemistry, Platinum compounds -- Therapeutic use, Photochemotherapy | ||||
Journal or Publication Title: | Dalton Transactions | ||||
Publisher: | Royal Society of Chemistry | ||||
ISSN: | 1477-9226 | ||||
Official Date: | 7 January 2011 | ||||
Dates: |
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Volume: | Vol.40 | ||||
Number: | No.1 | ||||
Page Range: | pp. 262-268 | ||||
DOI: | 10.1039/c0dt00546k | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC), Medical Research Council (Great Britain) (MRC) |
Data sourced from Thomson Reuters' Web of Knowledge
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